MGI phenotypes (allele matching)
- no phenotypic analysis / MGI
STOCK Mlanatm1.1Bee/Cnbc
| Status | Available to order |
| EMMA ID | EM:05333 |
| International strain name | STOCK Mlanatm1.1Bee/Cnbc |
| Alternative name | Mlana |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Mlanatm1.1Bee, |
| Gene/Transgene symbol | Mlana |
Information from provider
| Provider | Friedrich Beermann |
| Provider affiliation | EPFL SV ISREC |
| Genetic information | A conditional allele of the Mart-1/Mlana gene was constructed by inserting loxP sites 5' to exon 2 (containing the ATG) and 3' to exon 3. A neomycin resistance cassette has been removed by flpase (leaving a frt site). Cre/loxP recombination is working and is able to generate a Mlana ko allele. |
| Phenotypic information | This conditional allele has no phenotype. Removal of loxP-flanked exons of Mlana in homozygous situation will result in a coat color dilution and absence of Mlana/Mart-1 protein. |
| Breeding history | The mouse was backcrossed at least twice to C57BL/6N. It is currently kept as homozygous x homozygous matings. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | homozygous C57BL/6N |
Disease and phenotype information
Literature references
- Coat color dilution in mice because of inactivation of the melanoma antigen MART-1.;Aydin Iraz T, Hummler Edith, Smit Nico P M, Beermann Friedrich, ;2012;Pigment cell & melanoma research;25;37-46; 21943097