C57BL/6NTac-Atg16l1tm1a(EUCOMM)Wtsi/WtsiCnbc

Status

Available to order

EMMA IDEM:05376
International strain nameC57BL/6NTac-Atg16l1tm1a(EUCOMM)Wtsi/WtsiCnbc
Alternative nameEPD0102_2_A02
Strain typeTargeted Mutant Strains
Allele/Transgene symbolAtg16l1tm1a(EUCOMM)Wtsi,
Gene/Transgene symbolAtg16l1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0102_2_A02. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain
Animals used for archivingheterozygous C57BL/6NTac, wild-type C57BL/6J
Stage of embryos2-cell

Disease and phenotype information

IMPC phenotypes (allele matching)
  • preweaning lethality, complete penetrance / IMPC
MGI phenotypes (allele matching)
  • increased circulating serum albumin level / MGI
  • increased mean corpuscular hemoglobin / MGI
  • overriding aortic valve / MGI
  • abnormal eye muscle morphology / MGI
  • thoracoschisis / MGI
  • perimembraneous ventricular septal defect / MGI
  • abnormal hepatic vein morphology / MGI
  • abnormal inferior vena cava valve morphology / MGI
  • abnormal intrathoracic topology of vagus nerve / MGI
  • absent hypoglossal nerve / MGI
  • abnormal hypoglossal nerve topology / MGI
  • absent segment of posterior cerebral artery / MGI
  • subcutaneous edema / MGI
  • absent ductus venosus valve / MGI
  • abnormal thymus topology / MGI
  • absent connection between subcutaneous lymph vessels and lymph sac / MGI
  • blood in lymph vessels / MGI
  • abnormal vitelline vein topology / MGI
  • prenatal lethality / MGI

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).