MGI phenotypes (allele matching)
STOCK Prnptm2Edin Tg(Prnp-PRNP)110Jmto/Cnbc
| Status | Available to order |
| EMMA ID | EM:05415 |
| International strain name | STOCK Prnptm2Edin Tg(Prnp-PRNP)110Jmto/Cnbc |
| Alternative name | Prpn tm2Edin tg(moPrpn BoPrP)110 Jmto |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Prnp-PRNP)110Jmto, |
| Gene/Transgene symbol | Tg(Prnp-PRNP)110Jmto |
Information from provider
| Provider | Juan Maria Torres |
| Provider affiliation | CISA, INIA |
| Genetic information | Reintroduction of bovine PrP constructs under the control of a murine PrP promoter on a murine PrPn -/- background. |
| Phenotypic information | Overexpression of bovine PrP in mice lacking expression of murine PrP. Level of expression of bovine PrP in brain is approximately 8-fold that in bovine brain. These mice are very susceptible to bovine prions. |
| Breeding history | The original line was produced on embryos obtained crossing B6CBAF1 females with 129P2/OlaHsd males. Founders were crossed to obtain homozygosis for both mutations without a specific breeding scheme. Mice are since then kept by crossing brother to sister. Approximately 15 generations. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | yes |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | homozygous mixed, homozygous mixed |
| Stage of embryos | 8-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Inherited Creutzfeldt-Jakob disease / Orphanet_282166
- Familial Alzheimer-like prion disease / Orphanet_280397
- Huntington disease-like 1 / Orphanet_157941
- PrP systemic amyloidosis / Orphanet_397606
- Fatal familial insomnia / Orphanet_466
- Gerstmann-Straussler-Scheinker syndrome / Orphanet_356
- Sporadic fatal insomnia / Orphanet_586130
Literature references
- Early detection of PrPres in BSE-infected bovine PrP transgenic mice.;Castilla J, Gutiérrez Adán A, Brun A, Pintado B, Ramírez M A, Parra B, Doyle D, Rogers M, Salguero F J, Sánchez C, Sánchez-Vizcaíno J M, Torres J M, ;2003;Archives of virology;148;677-91; 12664293
- Different behavior toward bovine spongiform encephalopathy infection of bovine prion protein transgenic mice with one extra repeat octapeptide insert mutation.;Castilla J, Gutiérrez-Adán A, Brun A, Pintado B, Parra B, Ramírez M A, Salguero F J, Díaz San Segundo F, Rábano A, Cano M J, Torres J M, ;2004;The Journal of neuroscience : the official journal of the Society for Neuroscience;24;2156-64; 14999066
- Vertical transmission of bovine spongiform encephalopathy prions evaluated in a transgenic mouse model.;Castilla J, Brun A, Díaz-San Segundo F, Salguero F J, Gutiérrez-Adán A, Pintado B, Ramírez M A, del Riego L, Torres J M, ;2005;Journal of virology;79;8665-8; 15956610
- Sheep-passaged bovine spongiform encephalopathy agent exhibits altered pathobiological properties in bovine-PrP transgenic mice.;Espinosa Juan Carlos, Andréoletti Olivier, Castilla Joaquín, Herva María Eugenia, Morales Mónica, Alamillo Elia, San-Segundo Fayna Díaz, Lacroux Caroline, Lugan Séverine, Salguero Francisco Javier, Langeveld Jan, Torres Juan María, ;2007;Journal of virology;81;835-43; 17079295