MGI phenotypes (allele matching)
STOCK Prnptm2Edin Tg(Prnp-PRNP)001Jmto/Cnbc
| Status | Available to order |
| EMMA ID | EM:05416 |
| International strain name | STOCK Prnptm2Edin Tg(Prnp-PRNP)001Jmto/Cnbc |
| Alternative name | tg(moPrpn PoPrP)001 Jmto |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Prnp-PRNP)001Jmto, |
| Gene/Transgene symbol | Tg(Prnp-PRNP)001Jmto |
Information from provider
| Provider | Juan Maria Torres |
| Provider affiliation | CISA, INIA |
| Genetic information | Reintroduction of porcine PrP constructs under the control of a murine PrP promoter on a murine PrPn -/- background. |
| Phenotypic information | Overexpression of porcine PrP in mice lacking expression of murine PrP. Level of expression of bovine PrP in brain is approximately 4-fold that in pig brain. These mice show a differential susceptibility to several prion diseases. |
| Breeding history | The original line was produced on embryos obtained crossing B6CBAF1 females with 129P2/OlaHsd males. Founders were crossed to obtain homozygosis for both mutations without a specific breeding scheme. Mice are since then kept by crossing brother to sister. Approximately 12 generations. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | yes |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | homozygous mixed, homozygous mixed |
| Stage of embryos | 8-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Inherited Creutzfeldt-Jakob disease / Orphanet_282166
- Familial Alzheimer-like prion disease / Orphanet_280397
- Huntington disease-like 1 / Orphanet_157941
- PrP systemic amyloidosis / Orphanet_397606
- Fatal familial insomnia / Orphanet_466
- Gerstmann-Straussler-Scheinker syndrome / Orphanet_356
- Sporadic fatal insomnia / Orphanet_586130
Literature references
- Subclinical bovine spongiform encephalopathy infection in transgenic mice expressing porcine prion protein.;Castilla Joaquín, Gutiérrez-Adán Alfonso, Brun Alejandro, Doyle Deirdre, Pintado Belén, Ramírez Miguel A, Salguero Francisco J, Parra Beatriz, Segundo Fayna Díaz San, Sánchez-Vizcaíno José M, Rogers Mark, Torres Juan M, ;2004;The Journal of neuroscience : the official journal of the Society for Neuroscience;24;5063-9; 15163699
- Transgenic mice expressing porcine prion protein resistant to classical scrapie but susceptible to sheep bovine spongiform encephalopathy and atypical scrapie.;Espinosa Juan Carlos, Herva María Eugenia, Andréoletti Olivier, Padilla Danielle, Lacroux Caroline, Cassard Hervé, Lantier Isabelle, Castilla Joaquin, Torres Juan Maria, ;2009;Emerging infectious diseases;15;1214-21; 19751582