C57BL/6NTac-Slc20a2tm1a(EUCOMM)Wtsi/Ieg

Status

Available to order

EMMA IDEM:05549
International strain nameC57BL/6NTac-Slc20a2tm1a(EUCOMM)Wtsi/Ieg
Alternative nameEPD0243_1_C06
Strain typeTargeted Mutant Strains
Allele/Transgene symbolSlc20a2tm1a(EUCOMM)Wtsi,
Gene/Transgene symbolSlc20a2
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Provider affiliationInstitute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0243_1_C06. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany
Animals used for archivingheterozygous C57BL/6NTacUSA, wild-type C57BL/6NTacUSA
Stage of embryos2-cell

Disease and phenotype information

MGI allele-associated human disease models

IMPC phenotypes (allele matching)
  • decreased bone mineral density / IMPC
  • kyphosis / IMPC
  • decreased body length / IMPC
  • abnormal lens morphology / IMPC
  • cataract / IMPC
  • abnormal iris morphology / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • abnormal bone structure / IMPC
  • decreased lean body mass / IMPC
  • abnormal spine curvature / IMPC
  • eyelids fail to open / IMPC
  • absent pinna reflex / IMPC
  • decreased total body fat amount / IMPC
  • increased grip strength / IMPC
  • abnormal incisor color / IMPC
  • decreased bone mineral content / IMPC
  • decreased fasted circulating glucose level / IMPC
MGI phenotypes (allele matching)
  • abnormal mineral level / MGI
  • decreased circulating phosphate level / MGI
  • abnormal cerebral cortex morphology / MGI
  • abnormal thalamus morphology / MGI
  • abnormal basal ganglion morphology / MGI
  • microgliosis / MGI
  • calcified brain / MGI
  • abnormal atrioventricular cushion morphology / MGI
  • abnormal forebrain morphology / MGI
  • small superior cervical ganglion / MGI
  • ectopic cartilage / MGI
  • fusion of vertebral arches / MGI
  • abnormal vena cava morphology / MGI
  • arteriovenous malformation / MGI
  • abnormal liver vasculature morphology / MGI
  • anomalous pulmonary venous connection / MGI
  • abnormal hypoglossal nerve topology / MGI
  • retropleural edema / MGI
  • subcutaneous edema / MGI
  • multiple persisting craniopharyngeal ducts / MGI
  • embryo tumor / MGI
  • embryo cyst / MGI

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).