STOCK Stmn2tm1.1Ics/Orl
Status | Available to order |
EMMA ID | EM:05572 |
International strain name | STOCK Stmn2tm1.1Ics/Orl |
Alternative name | STMN2-KO |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Stmn2tm1.1Ics, |
Gene/Transgene symbol | Stmn2 |
Information from provider
Provider | Andre SOBEL |
Provider affiliation | UMRS 839 - Institut du Fer à Moulin, Inserm/UPMC |
Additional owner | Institut Clinique de la Souris (ICS), Illkirch/Strasbourg, France |
Genetic information | A cKO mouse was first constructed with loxP sites before and after exon 3 of the Stmn2 gene and crossed with a cre recombinase-expressing mouse leading to the deletion of exon 3. |
Phenotypic information | No major metabolic or behavioral phenotypic modification of heterozygous mice was observed in a standard phenotyping protocol; no significant anatomical anomaly was observed in homozygous mice at embryonic day 18.5, but they die shortly after birth (Institut de la Clinique de la Souris). |
Breeding history | Current genotype: C57BL/6J 0,0968%; C57BL/6N 6,1532%; 129/SvPas 0,7812%; C57BL/6NTac 92,9688% F0 |
References |
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Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | not known |
Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Animals used for archiving | heterozygous C57BL/6N, wild-type C57BL/6N |
Literature references
- Stathmin: a relay phosphoprotein for multiple signal transduction?;Sobel A, ;1991;Trends in biochemical sciences;16;301-5; 1957351
- Stathmin and its phosphoprotein family: general properties, biochemical and functional interaction with tubulin.;Curmi P A, Gavet O, Charbaut E, Ozon S, Lachkar-Colmerauer S, Manceau V, Siavoshian S, Maucuer A, Sobel A, ;1999;Cell structure and function;24;345-57; 15216892
- Differential, regional, and cellular expression of the stathmin family transcripts in the adult rat brain.;Ozon S, El Mestikawy S, Sobel A, ;1999;Journal of neuroscience research;56;553-64; 10369222
- Stathmin family proteins display specific molecular and tubulin binding properties.;Charbaut E, Curmi P A, Ozon S, Lachkar S, Redeker V, Sobel A, ;2001;The Journal of biological chemistry;276;16146-54; 11278715
- The 4 A X-ray structure of a tubulin:stathmin-like domain complex.;Gigant B, Curmi P A, Martin-Barbey C, Charbaut E, Lachkar S, Lebeau L, Siavoshian S, Sobel A, Knossow M, ;2000;Cell;102;809-16; 11030624
- Regulation and subcellular localization of the microtubule-destabilizing stathmin family phosphoproteins in cortical neurons.;Gavet Olivier, El Messari Saïd, Ozon Sylvie, Sobel André, ;2002;Journal of neuroscience research;68;535-50; 12111843
- Expression of stathmin family genes in human tissues: non-neural-restricted expression for SCLIP.;Bièche Ivan, Maucuer Alexandre, Laurendeau Ingrid, Lachkar Sylvie, Spano Anthony J, Frankfurter Anthony, Lévy Pascale, Manceau Valérie, Sobel André, Vidaud Michel, Curmi Patrick A, ;2003;Genomics;81;400-10; 12676564
- Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain.;Ravelli Raimond B G, Gigant Benoît, Curmi Patrick A, Jourdain Isabelle, Lachkar Sylvie, Sobel André, Knossow Marcel, ;2004;Nature;428;198-202; 15014504
- The "SCG10-LIke Protein" SCLIP is a novel regulator of axonal branching in hippocampal neurons, unlike SCG10.;Poulain Fabienne E, Sobel André, ;2007;Molecular and cellular neurosciences;34;137-46; 17145186
- SCLIP is crucial for the formation and development of the Purkinje cell dendritic arbor.;Poulain Fabienne E, Chauvin Stéphanie, Wehrlé Rosine, Desclaux Mathieu, Mallet Jacques, Vodjdani Guilan, Dusart Isabelle, Sobel André, ;2008;The Journal of neuroscience : the official journal of the Society for Neuroscience;28;7387-98; 18632943
- Normal development of mice lacking metablastin (P19), a phosphoprotein implicated in cell cycle regulation.;Schubart U K, Yu J, Amat J A, Wang Z, Hoffmann M K, Edelmann W, ;1996;The Journal of biological chemistry;271;14062-6; 8662897
- stathmin, a gene enriched in the amygdala, controls both learned and innate fear.;Shumyatsky Gleb P, Malleret Gaël, Shin Ryong-Moon, Takizawa Shuichi, Tully Keith, Tsvetkov Evgeny, Zakharenko Stanislav S, Joseph Jamie, Vronskaya Svetlana, Yin DeQi, Schubart Ulrich K, Kandel Eric R, Bolshakov Vadim Y, ;2005;Cell;123;697-709; 16286011
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