STOCK Stmn2tm1.1Ics/Orl

Status

Available to order

EMMA IDEM:05572
International strain nameSTOCK Stmn2tm1.1Ics/Orl
Alternative nameSTMN2-KO
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolStmn2tm1.1Ics,
Gene/Transgene symbolStmn2

Information from provider

ProviderAndre SOBEL
Provider affiliationUMRS 839 - Institut du Fer à Moulin, Inserm/UPMC
Additional ownerInstitut Clinique de la Souris (ICS), Illkirch/Strasbourg, France
Genetic informationA cKO mouse was first constructed with loxP sites before and after exon 3 of the Stmn2 gene and crossed with a cre recombinase-expressing mouse leading to the deletion of exon 3.
Phenotypic informationNo major metabolic or behavioral phenotypic modification of heterozygous mice was observed in a standard phenotyping protocol; no significant anatomical anomaly was observed in homozygous mice at embryonic day 18.5, but they die shortly after birth (Institut de la Clinique de la Souris).
Breeding historyCurrent genotype: C57BL/6J 0,0968%; C57BL/6N 6,1532%; 129/SvPas 0,7812%; C57BL/6NTac 92,9688% F0
References
  • Stathmin: a relay phosphoprotein for multiple signal transduction?;Sobel A, ;1991;Trends in biochemical sciences;16;301-5; 1957351
  • Stathmin and its phosphoprotein family: general properties, biochemical and functional interaction with tubulin.;Curmi P A, Gavet O, Charbaut E, Ozon S, Lachkar-Colmerauer S, Manceau V, Siavoshian S, Maucuer A, Sobel A, ;1999;Cell structure and function;24;345-57; 15216892
  • Differential, regional, and cellular expression of the stathmin family transcripts in the adult rat brain.;Ozon S, El Mestikawy S, Sobel A, ;1999;Journal of neuroscience research;56;553-64; 10369222
  • Stathmin family proteins display specific molecular and tubulin binding properties.;Charbaut E, Curmi P A, Ozon S, Lachkar S, Redeker V, Sobel A, ;2001;The Journal of biological chemistry;276;16146-54; 11278715
  • The 4 A X-ray structure of a tubulin:stathmin-like domain complex.;Gigant B, Curmi P A, Martin-Barbey C, Charbaut E, Lachkar S, Lebeau L, Siavoshian S, Sobel A, Knossow M, ;2000;Cell;102;809-16; 11030624
  • Regulation and subcellular localization of the microtubule-destabilizing stathmin family phosphoproteins in cortical neurons.;Gavet Olivier, El Messari Saïd, Ozon Sylvie, Sobel André, ;2002;Journal of neuroscience research;68;535-50; 12111843
  • Expression of stathmin family genes in human tissues: non-neural-restricted expression for SCLIP.;Bièche Ivan, Maucuer Alexandre, Laurendeau Ingrid, Lachkar Sylvie, Spano Anthony J, Frankfurter Anthony, Lévy Pascale, Manceau Valérie, Sobel André, Vidaud Michel, Curmi Patrick A, ;2003;Genomics;81;400-10; 12676564
  • Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain.;Ravelli Raimond B G, Gigant Benoît, Curmi Patrick A, Jourdain Isabelle, Lachkar Sylvie, Sobel André, Knossow Marcel, ;2004;Nature;428;198-202; 15014504
  • The "SCG10-LIke Protein" SCLIP is a novel regulator of axonal branching in hippocampal neurons, unlike SCG10.;Poulain Fabienne E, Sobel André, ;2007;Molecular and cellular neurosciences;34;137-46; 17145186
  • SCLIP is crucial for the formation and development of the Purkinje cell dendritic arbor.;Poulain Fabienne E, Chauvin Stéphanie, Wehrlé Rosine, Desclaux Mathieu, Mallet Jacques, Vodjdani Guilan, Dusart Isabelle, Sobel André, ;2008;The Journal of neuroscience : the official journal of the Society for Neuroscience;28;7387-98; 18632943
  • Normal development of mice lacking metablastin (P19), a phosphoprotein implicated in cell cycle regulation.;Schubart U K, Yu J, Amat J A, Wang Z, Hoffmann M K, Edelmann W, ;1996;The Journal of biological chemistry;271;14062-6; 8662897
  • stathmin, a gene enriched in the amygdala, controls both learned and innate fear.;Shumyatsky Gleb P, Malleret Gaël, Shin Ryong-Moon, Takizawa Shuichi, Tully Keith, Tsvetkov Evgeny, Zakharenko Stanislav S, Joseph Jamie, Vronskaya Svetlana, Yin DeQi, Schubart Ulrich K, Kandel Eric R, Bolshakov Vadim Y, ;2005;Cell;123;697-709; 16286011
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivingheterozygous C57BL/6N, wild-type C57BL/6N

Literature references

  • Stathmin: a relay phosphoprotein for multiple signal transduction?;Sobel A, ;1991;Trends in biochemical sciences;16;301-5; 1957351
  • Stathmin and its phosphoprotein family: general properties, biochemical and functional interaction with tubulin.;Curmi P A, Gavet O, Charbaut E, Ozon S, Lachkar-Colmerauer S, Manceau V, Siavoshian S, Maucuer A, Sobel A, ;1999;Cell structure and function;24;345-57; 15216892
  • Differential, regional, and cellular expression of the stathmin family transcripts in the adult rat brain.;Ozon S, El Mestikawy S, Sobel A, ;1999;Journal of neuroscience research;56;553-64; 10369222
  • Stathmin family proteins display specific molecular and tubulin binding properties.;Charbaut E, Curmi P A, Ozon S, Lachkar S, Redeker V, Sobel A, ;2001;The Journal of biological chemistry;276;16146-54; 11278715
  • The 4 A X-ray structure of a tubulin:stathmin-like domain complex.;Gigant B, Curmi P A, Martin-Barbey C, Charbaut E, Lachkar S, Lebeau L, Siavoshian S, Sobel A, Knossow M, ;2000;Cell;102;809-16; 11030624
  • Regulation and subcellular localization of the microtubule-destabilizing stathmin family phosphoproteins in cortical neurons.;Gavet Olivier, El Messari Saïd, Ozon Sylvie, Sobel André, ;2002;Journal of neuroscience research;68;535-50; 12111843
  • Expression of stathmin family genes in human tissues: non-neural-restricted expression for SCLIP.;Bièche Ivan, Maucuer Alexandre, Laurendeau Ingrid, Lachkar Sylvie, Spano Anthony J, Frankfurter Anthony, Lévy Pascale, Manceau Valérie, Sobel André, Vidaud Michel, Curmi Patrick A, ;2003;Genomics;81;400-10; 12676564
  • Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain.;Ravelli Raimond B G, Gigant Benoît, Curmi Patrick A, Jourdain Isabelle, Lachkar Sylvie, Sobel André, Knossow Marcel, ;2004;Nature;428;198-202; 15014504
  • The "SCG10-LIke Protein" SCLIP is a novel regulator of axonal branching in hippocampal neurons, unlike SCG10.;Poulain Fabienne E, Sobel André, ;2007;Molecular and cellular neurosciences;34;137-46; 17145186
  • SCLIP is crucial for the formation and development of the Purkinje cell dendritic arbor.;Poulain Fabienne E, Chauvin Stéphanie, Wehrlé Rosine, Desclaux Mathieu, Mallet Jacques, Vodjdani Guilan, Dusart Isabelle, Sobel André, ;2008;The Journal of neuroscience : the official journal of the Society for Neuroscience;28;7387-98; 18632943
  • Normal development of mice lacking metablastin (P19), a phosphoprotein implicated in cell cycle regulation.;Schubart U K, Yu J, Amat J A, Wang Z, Hoffmann M K, Edelmann W, ;1996;The Journal of biological chemistry;271;14062-6; 8662897
  • stathmin, a gene enriched in the amygdala, controls both learned and innate fear.;Shumyatsky Gleb P, Malleret Gaël, Shin Ryong-Moon, Takizawa Shuichi, Tully Keith, Tsvetkov Evgeny, Zakharenko Stanislav S, Joseph Jamie, Vronskaya Svetlana, Yin DeQi, Schubart Ulrich K, Kandel Eric R, Bolshakov Vadim Y, ;2005;Cell;123;697-709; 16286011

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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