STOCK Otx1tm4(cre)Asim/Cnrm
Status | Available to order |
EMMA ID | EM:05622 |
International strain name | STOCK Otx1tm4(cre)Asim/Cnrm |
Alternative name | Otx1-Cre |
Strain type | Targeted Mutant Strains : Knock-in |
Allele/Transgene symbol | Otx1tm4(cre)Asim, |
Gene/Transgene symbol | Otx1 |
Information from provider
Provider | Antonio Simeone |
Provider affiliation | Ceinge Biotecnologie Avanzate |
Genetic information | Otx1 exon 1 and 2 are replaced with cre recombinase gene by homologous recombination. |
Phenotypic information | Homozygous mice showed spontaneous epileptic behaviour and reduction of brain weight by about 25% and females lack of parental care. |
Breeding history | Mice were always maintained in a mixed C57BL/6 and DBA/2 genetic background. |
References |
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Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain.;Puelles Eduardo, Acampora Dario, Lacroix Emmanuel, Signore Massimo, Annino Alessandro, Tuorto Francesca, Filosa Stefania, Corte Giorgio, Wurst Wolfgang, Ang Siew-Lan, Simeone Antonio, ;2003;Nature neuroscience;6;453-60; 12652306
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