STOCK Otx1tm4(cre)Asim/Cnrm

Status

Available to order

EMMA IDEM:05622
International strain nameSTOCK Otx1tm4(cre)Asim/Cnrm
Alternative nameOtx1-Cre
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolOtx1tm4(cre)Asim,
Gene/Transgene symbolOtx1

Information from provider

ProviderAntonio Simeone
Provider affiliationCeinge Biotecnologie Avanzate
Genetic informationOtx1 exon 1 and 2 are replaced with cre recombinase gene by homologous recombination.
Phenotypic informationHomozygous mice showed spontaneous epileptic behaviour and reduction of brain weight by about 25% and females lack of parental care.
Breeding historyMice were always maintained in a mixed C57BL/6 and DBA/2 genetic background.
References
  • Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain.;Puelles Eduardo, Acampora Dario, Lacroix Emmanuel, Signore Massimo, Annino Alessandro, Tuorto Francesca, Filosa Stefania, Corte Giorgio, Wurst Wolfgang, Ang Siew-Lan, Simeone Antonio, ;2003;Nature neuroscience;6;453-60; 12652306
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Literature references

  • Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain.;Puelles Eduardo, Acampora Dario, Lacroix Emmanuel, Signore Massimo, Annino Alessandro, Tuorto Francesca, Filosa Stefania, Corte Giorgio, Wurst Wolfgang, Ang Siew-Lan, Simeone Antonio, ;2003;Nature neuroscience;6;453-60; 12652306

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).