STOCK Otx2tm2Asim/Cnrm

Status

Available to order

EMMA IDEM:05630
International strain nameSTOCK Otx2tm2Asim/Cnrm
Alternative nameOtx2-λ
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolOtx2tm2Asim,
Gene/Transgene symbolOtx2

Information from provider

ProviderAntonio Simeone
Provider affiliationCeinge Biotecnologie Avanzate
Genetic informationInsertion of a 300bp fragment of lambda phage DNA in the 3 prime UTR of Otx2.
Phenotypic informationHomozygous embryos exhibited proper gastrulation and normal patterning of the early anterior neural plate, but from 8.5 days post coitum they developed severe forebrain and midbrain abnormalities.
Breeding historyTargeted mutation was introduced in HM-1 ES cells. Mice were always maintained in a mixed C57BL/6 and DBA/2 genetic background.
References
  • Forebrain and midbrain development requires epiblast-restricted Otx2 translational control mediated by its 3' UTR.;Boyl P P, Signore M, Acampora D, Martinez-Barbera J P, Ilengo C, Annino A, Corte G, Simeone A, ;2001;Development (Cambridge, England);128;2989-3000; 11532921
Homozygous fertileno
Homozygous viableno
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • abnormal brain development / MGI
  • abnormal forebrain development / MGI
  • abnormal midbrain development / MGI
  • abnormal first pharyngeal arch morphology / MGI
  • acephaly / MGI
  • abnormal maxillary prominence morphology / MGI
  • microcephaly / MGI
  • exencephaly / MGI
  • open neural tube / MGI
  • anencephaly / MGI
  • reduced fertility / MGI
  • abnormal motor capabilities/coordination/movement / MGI
  • decreased midbrain size / MGI
  • decreased forebrain size / MGI

Literature references

  • Forebrain and midbrain development requires epiblast-restricted Otx2 translational control mediated by its 3' UTR.;Boyl P P, Signore M, Acampora D, Martinez-Barbera J P, Ilengo C, Annino A, Corte G, Simeone A, ;2001;Development (Cambridge, England);128;2989-3000; 11532921

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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