STOCK Otx2tm1(OTX1)Asim/Cnrm

Status

Available to order

EMMA IDEM:05631
International strain nameSTOCK Otx2tm1(OTX1)Asim/Cnrm
Alternative nameOtx2-hOtx1
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolOtx2tm1(OTX1)Asim,
Gene/Transgene symbolOtx2

Information from provider

ProviderAntonio Simeone
Provider affiliationCeinge Biotecnologie Avanzate
Genetic informationGene replacement of Otx2 with human Otx1 gene by homologous recombination.
Phenotypic informationAbout 50% of the expected homozygous embryos reached the end of gestation showing a dramatic headless phenotype even though about 15% of them showed residual, heavily abnormal craniofacial structures.
Breeding historyTargeted mutation was introduced in HM-1 ES cells. Mice were always maintained in a mixed C57BL/6 and DBA/2 genetic background.
References
  • Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulation.;Acampora D, Avantaggiato V, Tuorto F, Briata P, Corte G, Simeone A, ;1998;Development (Cambridge, England);125;5091-104; 9811592
Homozygous fertileno
Homozygous viableno
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • abnormal forebrain development / MGI
  • abnormal midbrain development / MGI
  • abnormal craniofacial development / MGI
  • abnormal embryonic neuroepithelium morphology / MGI
  • abnormal first pharyngeal arch morphology / MGI
  • acephaly / MGI
  • abnormal maxillary prominence morphology / MGI
  • abnormal cephalic neural fold morphology / MGI
  • rostral body truncation / MGI
  • abnormal anterior head development / MGI

Literature references

  • Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulation.;Acampora D, Avantaggiato V, Tuorto F, Briata P, Corte G, Simeone A, ;1998;Development (Cambridge, England);125;5091-104; 9811592

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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