STOCK Dlx5tm1Levi/Cnrm

Status

Available to order

EMMA IDEM:05637
International strain nameSTOCK Dlx5tm1Levi/Cnrm
Alternative nameDlx5-LacZ
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolDlx5tm1Levi,
Gene/Transgene symbolDlx5

Information from provider

ProviderAntonio Simeone
Provider affiliationCeinge Biotecnologie Avanzate
Genetic informationDlx5 is replaced with LacZ gene by homologous recombination.
Phenotypic informationHomozygous mutants die shortly after birth with a swollen abdomen. They present a complex phenotype characterised by craniofacial abnormalities affecting derivatives of the first four branchial arches, severe malformations of the vestibular organ, a delayed ossification of the roof of the skull and abnormal osteogenesis.
Breeding historyTargeted mutation was introduced in HM-1 ES cells. Mice were always maintained in a mixed C57BL/6 and DBA/2 genetic background.
References
  • Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5.;Acampora D, Merlo G R, Paleari L, Zerega B, Postiglione M P, Mantero S, Bober E, Barbieri O, Simeone A, Levi G, ;1999;Development (Cambridge, England);126;3795-809; 10433909
Homozygous fertileno
Homozygous viableno
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • abnormal inner ear vestibule morphology / MGI
  • abnormal otic capsule morphology / MGI
  • delayed bone ossification / MGI
  • abnormal neurocranium morphology / MGI
  • abnormal basioccipital bone morphology / MGI
  • large anterior fontanelle / MGI
  • short mandible / MGI
  • short maxilla / MGI
  • abnormal cell proliferation / MGI
  • absent palatine bone horizontal plate / MGI
  • abnormal cranium morphology / MGI
  • short snout / MGI
  • exencephaly / MGI
  • distended abdomen / MGI
  • hypoactivity / MGI
  • abnormal suckling behavior / MGI
  • respiratory distress / MGI
  • abnormal thyroid cartilage morphology / MGI
  • abnormal semicircular canal morphology / MGI
  • abnormal hyoid bone morphology / MGI
  • decreased lateral semicircular canal size / MGI
  • absent posterior semicircular canal / MGI
  • absent superior semicircular canal / MGI
  • abnormal alisphenoid bone morphology / MGI
  • ectopic cartilage / MGI
  • abnormal craniofacial development / MGI
  • absent stapes / MGI
  • abnormal crista ampullaris morphology / MGI
  • abnormal crista ampullaris neuroepithelium morphology / MGI
  • abnormal pterygoid bone morphology / MGI
  • small nasal bone / MGI
  • short nasal bone / MGI
  • absent mandibular coronoid process / MGI
  • abnormal Meckel's cartilage morphology / MGI
  • decreased tympanic ring size / MGI
  • abnormal styloid process morphology / MGI
  • abnormal bone ossification / MGI
  • abnormal gonial bone morphology / MGI
  • abnormal osteoblast differentiation / MGI
  • meteorism / MGI
  • absent gastric milk in neonates / MGI
  • cleft secondary palate / MGI
  • decreased maxillary shelf size / MGI
  • abnormal hyoid bone greater horn morphology / MGI
  • abnormal hyoid bone lesser horn morphology / MGI
  • delayed cranial suture closure / MGI
  • neonatal lethality, complete penetrance / MGI
  • abnormal head development / MGI
  • short Meckel's cartilage / MGI
  • ectopic cranial bone / MGI
  • wide cranial sutures / MGI
  • Wormian bones / MGI
  • short styloid process / MGI
  • abnormal cochlea morphology / MGI
  • absent semicircular canals / MGI
  • decreased cochlear coiling / MGI
  • otic vesicle hypoplasia / MGI
  • abnormal vestibular saccular macula morphology / MGI
  • abnormal utricular macula morphology / MGI
  • enlarged utricle / MGI
  • abnormal vestibular saccule morphology / MGI
  • short endolymphatic duct / MGI

Literature references

  • Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5.;Acampora D, Merlo G R, Paleari L, Zerega B, Postiglione M P, Mantero S, Bober E, Barbieri O, Simeone A, Levi G, ;1999;Development (Cambridge, England);126;3795-809; 10433909

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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