STOCK Otx2tm12.1Asim/Cnrm

Status

Available to order

EMMA IDEM:05641
International strain nameSTOCK Otx2tm12.1Asim/Cnrm
Alternative nameOtx2 RK-AA
Strain typeTargeted Mutant Strains : Point mutation
Allele/Transgene symbolOtx2tm12.1Asim,
Gene/Transgene symbolOtx2

Information from provider

ProviderAntonio Simeone
Provider affiliationCeinge Biotecnologie Avanzate
Genetic informationReplacement of the aminoacids Arg 36 and Lys 37 with two Ala (R36A, K37A).
Phenotypic informationEye problems, lowering of diopters.
ReferencesNone available
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • abnormal rod electrophysiology / MGI
  • vision/eye phenotype / MGI
  • decreased retinal ganglion cell number / MGI
  • decreased retinal cone cell number / MGI
  • thin retinal inner nuclear layer / MGI
  • thin retinal outer nuclear layer / MGI
  • abnormal head morphology / MGI
  • forebrain hypoplasia / MGI
  • neonatal lethality, complete penetrance / MGI
  • midbrain hypoplasia / MGI
  • anophthalmia / MGI
  • microphthalmia / MGI
  • abnormal iris morphology / MGI
  • abnormal retina morphology / MGI
  • decreased retinal photoreceptor cell number / MGI
  • abnormal optic nerve morphology / MGI
  • nervous system phenotype / MGI
  • abnormal cone electrophysiology / MGI
  • abnormal retinal pigment epithelium morphology / MGI
  • abnormal horizontal cell morphology / MGI
  • abnormal retinal bipolar cell morphology / MGI
  • decreased visual acuity / MGI
  • mortality/aging / MGI

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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