STOCK Mlanatm1.2Bee/Cnbc
Status | Available to order |
EMMA ID | EM:05667 |
International strain name | STOCK Mlanatm1.2Bee/Cnbc |
Alternative name | Mlana |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Mlanatm1.2Bee, |
Gene/Transgene symbol | Mlana |
Information from provider
Provider | Friedrich Beermann |
Provider affiliation | EPFL SV ISREC |
Genetic information | Mlana/Mart-1 were deleted (in vivo) by constitutive (germline) deletion of exon 2 (containing ATG) and exon 3 from loxP sites placed in the respective introns. DNA, RNA and protein of the deleted region (and of the whole protein) were not detected in homozygous Mlana-mutant mice |
Phenotypic information | Mice with homozygous deletion of Mlana are viable, and not reduced in fertility and physiology. These mice display a pigmentation phenotype, with slightly lighter fur. Biochemical and electron microscopy suggest a modification of melanosome structure |
Breeding history | Strain was backcrossed at least 3-4 times to C57BL/6N, and kept as heterozygous for ease of backcrossing. To produce mutant mice for shipment, we have interbred heterozygous mutant mice. |
References |
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Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
Animals used for archiving | homozygous 0 |
Disease and phenotype information
MGI phenotypes (allele matching)
Literature references
- Coat color dilution in mice because of inactivation of the melanoma antigen MART-1.;Aydin Iraz T, Hummler Edith, Smit Nico P M, Beermann Friedrich, ;2012;Pigment cell & melanoma research;25;37-46; 21943097
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