STOCK Fntbtm1Bbd/Cnbc
| Status | Available to order |
| EMMA ID | EM:05943 |
| International strain name | STOCK Fntbtm1Bbd/Cnbc |
| Alternative name | Fntb |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Fntbtm1Bbd, |
| Gene/Transgene symbol | Fntb |
Information from provider
| Provider | Mariano Barbacid |
| Provider affiliation | Molecular Oncology, Centro Nacional de Investigaciones Oncologicas |
| Genetic information | Exon 3 of the gene is flanked by loxP sites. Exon 3 encodes the catalytic subunit of the protein. |
| Phenotypic information | Before Cre mediated recombination there is no phenotype associated to this allele. The knockout allele is embryonic lethal in homozygosis. Embryos die at around E6.5. |
| Breeding history | Chimeras were crossed with CD1 females for germ line transmission analysis. Heterozygous offspring was crossed with Tg(CMV-cre)1Nagy for neomycin resistance gene excision. Offspring was intercrossed to obtain homozygous animals for the Fntb_lox allele and maintained in homozygosis. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous mixed |
Literature references
- Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development.;Mijimolle Nieves, Velasco Juan, Dubus Pierre, Guerra Carmen, Weinbaum Carolyn A, Casey Patrick J, Campuzano Victoria, Barbacid Mariano, ;2005;Cancer cell;7;313-24; 15837621