STOCK Fli1tm1.1Morl/Orl
| Status | Available to order |
| EMMA ID | EM:05992 |
| International strain name | STOCK Fli1tm1.1Morl/Orl |
| Alternative name | Fli1-KO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Fli1tm1.1Morl, |
| Gene/Transgene symbol | Fli1 |
Information from provider
| Provider | Francois Morle |
| Provider affiliation | CGPhyMC , CNRS UMR5534 |
| Genetic information | This strain carries a single LoxP in place of the whole coding of Fli1 gene exon 9. This strain has been generated by crossing mice harboring Fli1-fl conditional allele with Sycp1Cre mice expressing Cre recombinase during male meiosis. |
| Phenotypic information | Heterozygotes Fli1/Fli1KO have no obvious phenotype. Although not directly tested homozygotes Fli1KO/Fli1KO are expected to die around E12 from hemorrhage and abnormal megakaryopoiesis due to loss of Fli1. |
| Breeding history | LoxP insertions at Fli1 locus were generated in 129P2 ES cells. Cells were injected in C57BL/6J blastocysts and backcrossed on C57BL/6J. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | heterozygous C57BL/6J |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Isolated delta-storage pool disease / Orphanet_248340
Literature references
- Inducible Fli-1 gene deletion in adult mice modifies several myeloid lineage commitment decisions and accelerates proliferation arrest and terminal erythrocytic differentiation.;Starck Joëlle, Weiss-Gayet Michèle, Gonnet Colette, Guyot Boris, Vicat Jean-Michel, Morlé François, ;2010;Blood;116;4795-805; 20733157