STOCK Gja5tm2.1Kwi/Cnrm
Status | Available to order |
EMMA ID | EM:06035 |
International strain name | STOCK Gja5tm2.1Kwi/Cnrm |
Alternative name | Cx40A96S |
Strain type | Targeted Mutant Strains : Knock-in |
Allele/Transgene symbol | Gja5tm2.1Kwi, |
Gene/Transgene symbol | Gja5 |
Information from provider
Provider | Klaus Willecke |
Provider affiliation | LIMES Institute, University of Bonn |
Genetic information | The coding sequence of Gja5 (Cx40) was replaced by the Cx40A96S coding sequence. The expression of the Cx40A96S mutation is coupled to an eGFP reporter sequence via an IRES sequence. The neomycin resistance gene for screening of ES cell clones was deleted via the flp recombinase/frt sites system. |
Phenotypic information | Homozygous Cx40A96S mice exhibit renin-dependent hypertension. |
Breeding history | The line was backcrossed at least 3 times to C57BL/6N. |
References |
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Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Familial atrial fibrillation / Orphanet_334
MGI phenotypes (allele matching)
Literature references
- The connexin 40 A96S mutation causes renin-dependent hypertension.;Lübkemeier Indra, Machura Katharina, Kurtz Lisa, Neubauer Björn, Dobrowolski Radek, Schweda Frank, Wagner Charlotte, Willecke Klaus, Kurtz Armin, ;2011;Journal of the American Society of Nephrology : JASN;22;1031-40; 21597036
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