- absent coat pigmentation / MGI
- diluted coat color / MGI
- abnormal coat/hair pigmentation / MGI
- absent eye pigmentation / MGI
- abnormal coat appearance / MGI
- decreased eye pigmentation / MGI
- mottled coat / MGI
- abnormal eye pigmentation / MGI
- belly spot / MGI
- hypopigmentation / MGI
- variegated eye pigmentation pattern / MGI
- decreased ear pigmentation / MGI
STOCK Tyrc Tg(Tyr)YRT3Lmon/Cnbc
Status | Available to order |
EMMA ID | EM:06054 |
International strain name | STOCK Tyrc Tg(Tyr)YRT3Lmon/Cnbc |
Alternative name | Stock HsdWin:NMRI;B6CBA-Tg(Tyr)YRT3/Lmon |
Strain type | Spontaneous |
Allele/Transgene symbol | Tyrc, |
Gene/Transgene symbol | Tyr |
Information from provider
Provider | Lluis Montoliu |
Provider affiliation | Departamento de Biologia Molecular y Celular, CNB-CSIC, Centro Nacional de Biotecnologia |
Genetic information | YAC YRT3 (Montoliu et al. 1996, EMBO J) carrying the Tyr expression domain, up to the locus control region (LCR), was re-injected (the original line was lost and could not be recovered from frozen material at DKFZ) into B6CBAF2 embryos and positive transgenic animals were backcrossed to stock albino outbred HsdWin:NMRI mice (less than 5 generations so far). |
Phenotypic information | Pigmented mice undistinguishable from wild-type agouti mice, as compared to non-transgenic albino NMRI mice. |
Breeding history | YAC YRT3 transgenic line originally detected in B6CBAF2 background and backcrossed to NMRI (currently less than 5 generations) where it is maintained now. |
References |
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Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
Animals used for archiving | wild-type NMRI, homozygous NMRI |
Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Temperature-sensitive oculocutaneous albinism type 1 / Orphanet_352737
- Oculocutaneous albinism type 1A / Orphanet_79431
- Oculocutaneous albinism type 1B / Orphanet_79434
- Minimal pigment oculocutaneous albinism type 1 / Orphanet_352734
- Ocular albinism with congenital sensorineural deafness / Orphanet_352740
MGI phenotypes (allele matching)
Literature references
- A locus control region at -12 kb of the tyrosinase gene.;Montoliu L, Umland T, Schütz G, ;1996;The EMBO journal;15;6026-34; 8947025
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