STOCK Tyrc Tg(Tyr)YRT3Lmon/Cnbc

Status

Available to order

EMMA IDEM:06054
International strain nameSTOCK Tyrc Tg(Tyr)YRT3Lmon/Cnbc
Alternative nameStock HsdWin:NMRI;B6CBA-Tg(Tyr)YRT3/Lmon
Strain typeSpontaneous
Allele/Transgene symbolTyrc,
Gene/Transgene symbolTyr

Information from provider

ProviderLluis Montoliu
Provider affiliationDepartamento de Biologia Molecular y Celular, CNB-CSIC, Centro Nacional de Biotecnologia
Genetic informationYAC YRT3 (Montoliu et al. 1996, EMBO J) carrying the Tyr expression domain, up to the locus control region (LCR), was re-injected (the original line was lost and could not be recovered from frozen material at DKFZ) into B6CBAF2 embryos and positive transgenic animals were backcrossed to stock albino outbred HsdWin:NMRI mice (less than 5 generations so far).
Phenotypic informationPigmented mice undistinguishable from wild-type agouti mice, as compared to non-transgenic albino NMRI mice.
Breeding historyYAC YRT3 transgenic line originally detected in B6CBAF2 background and backcrossed to NMRI (currently less than 5 generations) where it is maintained now.
References
  • A locus control region at -12 kb of the tyrosinase gene.;Montoliu L, Umland T, Schütz G, ;1996;The EMBO journal;15;6026-34; 8947025
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain
Animals used for archivingwild-type NMRI, homozygous NMRI
Stage of embryos2-cell

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • absent coat pigmentation / MGI
  • diluted coat color / MGI
  • abnormal coat/hair pigmentation / MGI
  • absent eye pigmentation / MGI
  • abnormal coat appearance / MGI
  • decreased eye pigmentation / MGI
  • mottled coat / MGI
  • abnormal eye pigmentation / MGI
  • belly spot / MGI
  • hypopigmentation / MGI
  • variegated eye pigmentation pattern / MGI
  • decreased ear pigmentation / MGI

Literature references

  • A locus control region at -12 kb of the tyrosinase gene.;Montoliu L, Umland T, Schütz G, ;1996;The EMBO journal;15;6026-34; 8947025

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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