Cnbc:NMRI-Tg(Wap-ALPP*)p1435Lmon

Status	Available to order
EMMA ID	EM:06055
International strain name	Cnbc:NMRI-Tg(Wap-ALPP*)p1435Lmon
Alternative name	stock HsdWin:NMRI-Tg(Wap-hSEAP)p1435Lmon
Strain type	Spontaneous
Allele/Transgene symbol	Tyr^c,
Gene/Transgene symbol	Tyr

Information from provider

Provider	Lluis Montoliu
Provider affiliation	Departamento de Biologia Molecular y Celular, CNB-CSIC, Centro Nacional de Biotecnologia
Genetic information	Plasmid pWap-SEAP, carrying 7.6 kb of mouse Wap sequences and the human SEAP reporter gene (Clontech) was injected into pronuclei of NMRI fertilized oocytes and resulted in transgenic mice founder line 1435, with >60 copies of transgene and no expression levels (chromosome position effects) in mammary gland, but high ectopic expression in kidney, muscle and lungs
Phenotypic information	No specific traits distinguishable from NMRI mice other than expression data reported.
Breeding history	Created and maintained in stock outbred albino HsdWin:NMRI
References	Hormone-induced modifications of the chromatin structure surrounding upstream regulatory regions conserved between the mouse and rabbit whey acidic protein genes.;Millot Benjamin, Montoliu Lluís, Fontaine Marie-Louise, Mata Teresa, Devinoy Eve, ;2003;The Biochemical journal;372;41-52; 12580766 Design of vectors for transgene expression: The use of genomic comparative approaches.;Montoliu Lluís, Roy Rosa, Regales Lucía, García-Díaz Angel, ;2009;Comparative immunology, microbiology and infectious diseases;32;81-90; 18328563
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Temperature-sensitive oculocutaneous albinism type 1 / Orphanet_352737
Oculocutaneous albinism type 1A / Orphanet_79431
Oculocutaneous albinism type 1B / Orphanet_79434
Minimal pigment oculocutaneous albinism type 1 / Orphanet_352734
Ocular albinism with congenital sensorineural deafness / Orphanet_352740

MGI phenotypes (allele matching)

absent coat pigmentation / MGI
diluted coat color / MGI
abnormal coat/hair pigmentation / MGI
absent eye pigmentation / MGI
abnormal coat appearance / MGI
decreased eye pigmentation / MGI
mottled coat / MGI
abnormal eye pigmentation / MGI
belly spot / MGI
hypopigmentation / MGI
variegated eye pigmentation pattern / MGI
decreased ear pigmentation / MGI

Literature references

Hormone-induced modifications of the chromatin structure surrounding upstream regulatory regions conserved between the mouse and rabbit whey acidic protein genes.;Millot Benjamin, Montoliu Lluís, Fontaine Marie-Louise, Mata Teresa, Devinoy Eve, ;2003;The Biochemical journal;372;41-52; 12580766
Design of vectors for transgene expression: The use of genomic comparative approaches.;Montoliu Lluís, Roy Rosa, Regales Lucía, García-Díaz Angel, ;2009;Comparative immunology, microbiology and infectious diseases;32;81-90; 18328563

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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