STOCK Pmeltm1.1Sson/Kctt
Status | Available to order |
EMMA ID | EM:06222 |
International strain name | STOCK Pmeltm1.1Sson/Kctt |
Alternative name | Pmel KO |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Pmeltm1.1Sson, |
Gene/Transgene symbol | Pmel |
Information from provider
Provider | Susanne Kerje |
Provider affiliation | IMBIM, Uppsala University |
Genetic information | Exons 2 and 3 of the Pmel 17 gene have been knocked out resulting in a non functional protein. |
Phenotypic information | Mice lacking PMEL have almost normal fur pigmentation. Loss of PMEL has a dramatic effect on the morphology of the melanosomes in skin, hair, and eye, such that the normally rod-shaped melanosomes in wild-type animals are spherical in the knockout mice. The knockout animals also have a substantial reduction in the content of black pigment in hair. |
Breeding history | The Pmel KO is maintained in a C57BL/6 background. |
References |
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Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | Karolinska Institutet, Stockholm, Sweden |
Disease and phenotype information
MGI phenotypes (allele matching)
Literature references
- Inactivation of Pmel alters melanosome shape but has only a subtle effect on visible pigmentation.;Hellström Anders R, Watt Brenda, Fard Shahrzad Shirazi, Tenza Danièle, Mannström Paula, Narfström Kristina, Ekesten Björn, Ito Shosuke, Wakamatsu Kazumasa, Larsson Jimmy, Ulfendahl Mats, Kullander Klas, Raposo Graça, Kerje Susanne, Hallböök Finn, Marks Michael S, Andersson Leif, ;2011;PLoS genetics;7;e1002285; 21949658
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