STOCK Nfkbiatm1Kbp Tg(KRT14-cre)1Cgn/Ieg
| Status | Available to order |
| EMMA ID | EM:06271 |
| International strain name | STOCK Nfkbiatm1Kbp Tg(KRT14-cre)1Cgn/Ieg |
| Alternative name | K14cre Ikba |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Nfkbiatm1Kbp, |
| Gene/Transgene symbol | Nfkbia |
Information from provider
| Provider | Rudolf Rupec |
| Provider affiliation | Derma AG |
| Genetic information | Inducible skin specific deletion of Nfkbia (promoter region containing essential regulatory NF-kappaB binding sites, the core promoter, and the first two exons) with cre-loxP system. Cre-expression linked to keratin 14. |
| Phenotypic information | Persistent skin inflammation; psoriasis like. |
| References |
|
| Homozygous fertile | no |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | heterozygous C57BL/6N, wild-type C57BL/6N |
| Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Nasopharyngeal carcinoma / Orphanet_150
- Hypohidrotic ectodermal dysplasia with immunodeficiency / Orphanet_98813
Literature references
- Crosstalk between keratinocytes and adaptive immune cells in an IkappaBalpha protein-mediated inflammatory disease of the skin.;Rebholz Bernd, Haase Ingo, Eckelt Birgit, Paxian Stephan, Flaig Michael J, Ghoreschi Kamran, Nedospasov Sergei A, Mailhammer Reinhard, Debey-Pascher Svenja, Schultze Joachim L, Weindl Günther, Förster Irmgard, Huss Ralf, Stratis Athanasios, Ruzicka Thomas, Röcken Martin, Pfeffer Klaus, Schmid Roland M, Rupec Rudolf A, ;2007;Immunity;27;296-307; 17692539
- Stroma-mediated dysregulation of myelopoiesis in mice lacking I kappa B alpha.;Rupec Rudolf A, Jundt Franziska, Rebholz Bernd, Eckelt Birgit, Weindl Günther, Herzinger Thomas, Flaig Michael J, Moosmann Sabine, Plewig Gerd, Dörken Bernd, Förster Irmgard, Huss Ralf, Pfeffer Klaus, ;2005;Immunity;22;479-91; 15845452