STOCK Nebtm2.1Chen/Cnrm

Status

Available to order

EMMA IDEM:07147
International strain nameSTOCK Nebtm2.1Chen/Cnrm
Alternative nameNebulin SH3 deleted
Strain typeTargeted Mutant Strains : Other targeted
Allele/Transgene symbolNebtm2.1Chen,
Gene/Transgene symbolNeb

Information from provider

ProviderMarie-Louise Bang
Provider affiliationUniversity of California San Diego
Genetic informationNebulin truncation resulting in deletion of its C-terminal SH3 domain encoded by nebulin's last exon, through replacement of residue I7097 with stop codons in all reading frames.
Phenotypic informationNebulin SH3 truncated mice do not exhibit any obvious skeletal muscle phenotype except for the generation of slightly lower isometric force at lower frequencies and potentially higher susceptibility to eccentric contraction-induced injury.
Breeding historyThe chimeric mice were crossed with Black Swiss mice to achieve germline transmission and were subsequently crossed once more with Black Swiss mice. After that they were kept in the mixed background.
References
  • The nebulin SH3 domain is dispensable for normal skeletal muscle structure but is required for effective active load bearing in mouse.;Yamamoto Daniel L, Vitiello Carmen, Zhang Jianlin, Gokhin David S, Castaldi Alessandra, Coulis Gerald, Piaser Fabio, Filomena Maria Carmela, Eggenhuizen Peter J, Kunderfranco Paolo, Camerini Serena, Takano Kazunori, Endo Takeshi, Crescenzi Marco, Luther Pradeep K L, Lieber Richard L, Chen Ju, Bang Marie-Louise, ;2013;Journal of cell science;126;5477-89; 24046450
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • abnormal muscle electrophysiology / MGI
  • increased susceptibility to injury / MGI
  • muscle phenotype / MGI

Literature references

  • The nebulin SH3 domain is dispensable for normal skeletal muscle structure but is required for effective active load bearing in mouse.;Yamamoto Daniel L, Vitiello Carmen, Zhang Jianlin, Gokhin David S, Castaldi Alessandra, Coulis Gerald, Piaser Fabio, Filomena Maria Carmela, Eggenhuizen Peter J, Kunderfranco Paolo, Camerini Serena, Takano Kazunori, Endo Takeshi, Crescenzi Marco, Luther Pradeep K L, Lieber Richard L, Chen Ju, Bang Marie-Louise, ;2013;Journal of cell science;126;5477-89; 24046450

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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