- increased granulocyte number / MGI
- abnormal spleen morphology / MGI
- spleen hypoplasia / MGI
- decreased body size / MGI
- arrested B cell differentiation / MGI
- decreased IgM level / MGI
- thymus hypoplasia / MGI
- arrested T cell differentiation / MGI
- increased susceptibility to infection / MGI
- abnormal effector T cell morphology / MGI
- increased natural killer cell mediated cytotoxicity / MGI
- decreased double-positive T cell number / MGI
- increased macrophage cell number / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- lymph node hypoplasia / MGI
- absent mature B cells / MGI
- abnormal T cell receptor V(D)J recombination / MGI
- abnormal immunoglobulin V(D)J recombination / MGI
- decreased thymocyte number / MGI
- lung inflammation / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal macrophage physiology / MGI
- colitis / MGI
- abnormal T-helper 1 physiology / MGI
- abnormal response to transplant / MGI
- abnormal interferon secretion / MGI
- abnormal chemokine secretion / MGI
- decreased susceptibility to bacterial infection induced morbidity/mortality / MGI
- abnormal intestinal mucosa morphology / MGI
- abnormal B cell morphology / MGI
- decreased susceptibility to parasitic infection / MGI
- decreased double-negative T cell number / MGI
- increased double-negative T cell number / MGI
- decreased susceptibility to type IV hypersensitivity reaction / MGI
- abnormal stomach mucosa morphology / MGI
- abnormal intestinal epithelium morphology / MGI
- abnormal B cell number / MGI
- decreased pre-B cell number / MGI
- decreased mature B cell number / MGI
- increased immature B cell number / MGI
- decreased immature B cell number / MGI
- abnormal gamma-delta T cell differentiation / MGI
STOCK Rag2tm1Fwa Thy1a Tg(TcraH-Y,TcrbH-Y)71Vbo/Orl
Status | Available to order |
EMMA ID | EM:07459 |
International strain name | STOCK Rag2tm1Fwa Thy1a Tg(TcraH-Y,TcrbH-Y)71Vbo/Orl |
Alternative name | Rag2-/- Tg HY +/+ Thy1.1 |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Rag2tm1Fwa, |
Gene/Transgene symbol | Rag2 |
Information from provider
Provider | Benedita Rocha |
Provider affiliation | INSERM U 1020, INSERM |
Additional owner | Frederick W. Alt, Harald von Boehmer |
Genetic information | Mutant mice bearing a transgenic alpha-beta TCR specific for the HY male antigen restricted to major histocompatibility complex (MHC) class I H2Db and deficient in the Rag2 recombinase gene (TgRAG2) were used to obtain monoclonal populations of CD8+T cells. |
Phenotypic information | Mice will have a single population of lymphocytes, those expressing the TCR transgene. |
Breeding history | Currently bred as homozygotes for the Rag2 knock-out mutation and the TCR transgene, Thya (Thy1.1) allotype. |
References |
|
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | yes |
Immunocompromised | yes |
Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Animals used for archiving | homozygous C57BL/6J, homozygous C57BL/6J |
Breeding at archiving centre | Homozygous for the three mutations |
Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Severe combined immunodeficiency due to complete RAG1/2 deficiency / Orphanet_331206
- Omenn syndrome / Orphanet_39041
- Combined immunodeficiency with granulomatosis / Orphanet_157949
MGI phenotypes (allele matching)
Literature references
- Differential requirements for survival and proliferation of CD8 naïve or memory T cells.;Tanchot C, Lemonnier F A, Pérarnau B, Freitas A A, Rocha B, ;1997;Science (New York, N.Y.);276;2057-62; 9197272
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