STOCK Mogtm1(cre)Gkl/Flmg
| Status | Available to order |
| EMMA ID | EM:08367 |
| International strain name | STOCK Mogtm1(cre)Gkl/Flmg |
| Alternative name | B6-Mog |
| Strain type | Targeted Mutant Strains : Other targeted |
| Allele/Transgene symbol | Mogtm1(cre)Gkl |
| Gene/Transgene symbol | Mog |
Information from provider
| Provider | George Kollias |
| Provider affiliation | BSRC Al. Fleming |
| Genetic information | The open reading frame of the Cre recombinase gene, followed by the human growth hormone polyadenylation signal and the neomycin resistance gene, has replaced all except the 5'-most segment of the first exon, the first intron and all but the 3'-most part of the second exon of the myelin oligodendrocyte glycoprotein gene, thus targeting Cre expression to oligodendrocytes (ODCs). Western blot analysis demonstrated that wild-type MOG protein is present in heterozygous and wild-type brains at comparable levels, but is not detectable in homozygous mutant brain. |
| Phenotypic information | Homozygous:Cre expression in oligodendrocytesHeterozygous:Cre expression in oligodendrocytes |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
| Animals used for archiving | heterozygous CBA x C57BL/6 |
Literature references
- Apoptosis of oligodendrocytes via Fas and TNF-R1 is a key event in the induction of experimental autoimmune encephalomyelitis.;Hövelmeyer Nadine, Hao Zhenyue, Kranidioti Ksanthi, Kassiotis George, Buch Thorsten, Frommer Friederike, von Hoch Lennart, Kramer Dana, Minichiello Liliana, Kollias George, Lassmann Hans, Waisman Ari, ;2005;Journal of immunology (Baltimore, Md. : 1950);175;5875-84; 16237080