STOCK Tg(TNFRSF1B)1334Gkl/Flmg
Status | Available to order |
EMMA ID | EM:08377 |
International strain name | STOCK Tg(TNFRSF1B)1334Gkl/Flmg |
Alternative name | CBA.B6-Tg(TNFRSF1B)1334Gkl/Flmg |
Strain type | Transgenic Strains |
Allele/Transgene symbol | Tg(TNFRSF1B)1334Gkl |
Gene/Transgene symbol | Tg(TNFRSF1B)1334Gkl |
Information from provider
Provider | George Kollias |
Provider affiliation | BSRC Al. Fleming |
Genetic information | Tg1334 mice contain as transgene a 70 kb DNA fragment comprising the entire human TNFR2 genomic sequence. These mice express human TNFR2 in a physiological relevant pattern and grow normally without displaying any pathological changes. |
Phenotypic information | Homozygous:No overt pathologyHeterozygous:No overt pathology |
References |
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Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
Animals used for archiving | heterozygous CBA x C57BL/6 |
Literature references
- A critical role of the p75 tumor necrosis factor receptor (p75TNF-R) in organ inflammation independent of TNF, lymphotoxin alpha, or the p55TNF-R.;Douni E, Kollias G, ;1998;The Journal of experimental medicine;188;1343-52; 9763613
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