STOCK Map3k7tm1.1Gkl/Flmg
| Status | Available to order |
| EMMA ID | EM:08404 |
| International strain name | STOCK Map3k7tm1.1Gkl/Flmg |
| Alternative name | TAK1FL/FL [B6-Map3k7tm1.1Gkl/Flmg] |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Map3k7tm1.1Gkl, |
| Gene/Transgene symbol | Map3k7 |
Information from provider
| Provider | George Kollias |
| Provider affiliation | BSRC Al. Fleming |
| Genetic information | A targeting vector was constructed in which a 0.6 kb fragment of Map3k7 containing exon 2 was flanked by loxP sites. The targeting vector also contained an FRT-neo-FRT selection cassette next to the first loxP site and before exon 2. |
| Phenotypic information | Homozygous:No overt phenotype.Heterozygous:No overt phenotype |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
| Animals used for archiving | homozygous C57BL/6J |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Cardiospondylocarpofacial syndrome / Orphanet_3238
- Frontometaphyseal dysplasia / Orphanet_1826
Literature references
- Myeloid TAKI [corrected] acts as a negative regulator of the LPS response and mediates resistance to endotoxemia.;Eftychi Christina, Karagianni Niki, Alexiou Maria, Apostolaki Maria, Kollias George, ;2012;PloS one;7;e31550; 22348103
- Inactivation of the deubiquitinase CYLD in hepatocytes causes apoptosis, inflammation, fibrosis, and cancer.;Nikolaou Kostas, Tsagaratou Ageliki, Eftychi Christina, Kollias George, Mosialos George, Talianidis Iannis, ;2012;Cancer cell;21;738-50; 22698400