- abnormal response/metabolism to endogenous compounds / MGI
- decreased circulating interleukin-6 level / MGI
- decreased sensitivity to induced morbidity/mortality / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- decreased sensitivity to xenobiotic induced morbidity/mortality / MGI
- abnormal sleep pattern / MGI
- impaired central nervous system regeneration / MGI
- increased sensitivity to induced cell death / MGI
- increased susceptibility to bacterial infection induced morbidity/mortality / MGI
- impaired humoral immune response / MGI
- decreased susceptibility to bacterial infection / MGI
- decreased circulating alanine transaminase level / MGI
- abnormal Peyer's patch morphology / MGI
- abnormal immune system physiology / MGI
- abnormal lymph node B cell domain morphology / MGI
- abnormal Peyer's patch follicle morphology / MGI
- increased susceptibility to bacterial infection / MGI
- decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
- increased susceptibility to parasitic infection / MGI
- increased susceptibility to type I hypersensitivity reaction / MGI
- decreased Peyer's patch number / MGI
- absent follicular dendritic cells / MGI
- decreased IgG1 level / MGI
- decreased interleukin-6 secretion / MGI
STOCK Tnfrsf1atm1Blt Tg(CD2/HBB-TNF*)5453Gkl/Flmg
Status | Available to order |
EMMA ID | EM:08448 |
International strain name | STOCK Tnfrsf1atm1Blt Tg(CD2/HBB-TNF*)5453Gkl/Flmg |
Alternative name | Tg5453 [CBA;B6-Tnfrsf1a |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Tnfrsf1atm1Blt, |
Gene/Transgene symbol | Tnfrsf1a |
Information from provider
Provider | George Kollias |
Provider affiliation | Immunology, BSRC Al. Fleming |
Genetic information | A mutant uncleavable form of the 26 kD protein was engineered by the deletion of the codons for the first to the twelfth amino acids of the wild type gene. This produces a membrane-associated protein that is bioactive. Under the control of the T cell specific human CD2 gene locus control region (LCR). |
Phenotypic information | Homozygous:N/AHeterozygous:Humanized transgenic mouse with a T-cell-target transmembrane human TNF deregulated expression, which results in the spontaneous development of arthritis pathology closely resembling that of human rheumatoid arthritis. |
References |
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Homozygous fertile | no |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
Animals used for archiving | heterozygous 0, wild-type (CBA x C57BL/6)F1 |
Stage of embryos | Morula |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Tumor necrosis factor receptor 1 associated periodic syndrome / Orphanet_32960
MGI phenotypes (allele matching)
Literature references
- Transmembrane TNF is sufficient to induce localized tissue toxicity and chronic inflammatory arthritis in transgenic mice.;Georgopoulos S, Plows D, Kollias G, ;1996;Journal of inflammation;46;86-97; 8734789
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