- increased monocyte cell number / IMPC
- decreased leukocyte cell number / IMPC
- increased granulocyte number / IMPC
- abnormal cornea morphology / IMPC
- corneal opacity / IMPC
- trunk curl / IMPC
- increased mean corpuscular volume / IMPC
- decreased B cell number / IMPC
- decreased T cell number / IMPC
- narrow eye opening / IMPC
- corneal vascularization / IMPC
- increased circulating sodium level / IMPC
- absent pinna reflex / IMPC
- increased NK cell number / IMPC
- decreased CD4-positive, alpha beta T cell number / IMPC
- decreased CD8-positive, alpha-beta T cell number / IMPC
- decreased mature B cell number / IMPC
- increased effector memory CD4-positive, alpha-beta T cell number / IMPC
- increased effector memory CD8-positive, alpha-beta T cell number / IMPC
B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH
Status | Available to order |
EMMA ID | EM:08571 |
International strain name | B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH |
Alternative name | EPD0090_5_B04 |
Strain type | Targeted Mutant Strains |
Allele/Transgene symbol | Spns2tm1b(KOMP)Wtsi, |
Gene/Transgene symbol | Spns2 |
Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
|
Information from provider
Provider | Wellcome Trust Sanger Institute |
Provider affiliation | Wellcome Trust Sanger Institute |
Genetic information | This mouse line originates from KOMP ES clone EPD0090_5_B04. For further details on the construction of this clone see the page at the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele using an X-linked CMV-Cre driver (EM:05414; C57BL/6N-Hprttm1(CMV-cre)Wtsi/WtsiOulu) for this purpose. Click here for more information on KOMP final vectors. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
IMPC phenotypes (allele matching)
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).