MGI phenotypes (allele matching)
STOCK Hmox1tm1.2Gkl/Flmg
| Status | Available to order |
| EMMA ID | EM:08992 |
| International strain name | STOCK Hmox1tm1.2Gkl/Flmg |
| Alternative name | B6.129-Hmox1 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Hmox1tm1.2Gkl, |
| Gene/Transgene symbol | Hmox1 |
Information from provider
| Provider | George Kollias |
| Provider affiliation | BSRC Al. Fleming |
| Genetic information | Germ line, cre mediated recombination was used to remove exon 3 through 4. The absence of protein expression was confirmed by Western blot analysis on thioglycollate-stimulated peritoneal macrophage. |
| Phenotypic information | Homozygous:Partial embryonic lethality is displayed. Mice appear to be anemic and develop a progressive chronic inflammatory disease characterized by enlarged spleens and hepatic inflammatory lesions. They die within 6 months because of presumed multi-organ failure.Heterozygous:No overt pathology. Mice exhibit fertility problems. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
| Animals used for archiving | heterozygous C57BL/6, wild-type C57BL/6 |
| Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Heme oxygenase-1 deficiency / Orphanet_562509
Literature references
- Myeloid heme oxygenase-1 regulates innate immunity and autoimmunity by modulating IFN-beta production.;Tzima Sotiria, Victoratos Panayiotis, Kranidioti Ksanthi, Alexiou Maria, Kollias George, ;2009;The Journal of experimental medicine;206;1167-79; 19398754