STOCK Pax7tm1(cre)Mrc Mapk14tm2Nbr/JpellH
| Status | Available to order |
| EMMA ID | EM:09446 |
| International strain name | STOCK Pax7tm1(cre)Mrc Mapk14tm2Nbr/JpellH |
| Alternative name | C57BL/6J- Mapk14tm2Nbr Pax7tm1(cre)Mrc |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Pax7tm1(cre)Mrc, |
| Gene/Transgene symbol | Pax7 |
Information from provider
| Provider | Sarah Shorne |
| Provider affiliation | Pharmacology, University of Cambridge |
| Genetic information | Knock-out of Mapk14/p38alpha only in the presence of cre recombinase. |
| Phenotypic information | Homozygous:Very mild growth retardation.Heterozygous:Unsure if exhibited in heterozygote. |
| Breeding history | p38flox mice, expressing loxP-flanked Mapk14/p38alpha, crossed with Pax7-cre mice. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | not known |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development.;Adams R H, Porras A, Alonso G, Jones M, Vintersten K, Panelli S, Valladares A, Perez L, Klein R, Nebreda A R, ;2000;Molecular cell;6;109-16; 10949032
- Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin.;Keller Charles, Hansen Mark S, Coffin Cheryl M, Capecchi Mario R, ;2004;Genes & development;18;2608-13; 15520281