STOCK Flt4tm2.1Ali/Oulu
| Status | Available to order |
| EMMA ID | EM:09463 |
| International strain name | STOCK Flt4tm2.1Ali/Oulu |
| Alternative name | Vegfr3flox/flox |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Flt4tm2.1Ali, |
| Gene/Transgene symbol | Flt4 |
Information from provider
| Provider | Kari Alitalo |
| Provider affiliation | Translational Cancer Biology Program, Wihuri Research Institute, University of Helsinki |
| Genetic information | Vegfr3 conditional mouse |
| Phenotypic information | Homozygous:Homozygous mice for this allele are viable and fertile, and do not display any pathological phenotype. When these mutant mice are bred to mice that express Cre recombinase, the resulting offspring will have the first exon and part of the first intron of the Vegfr3 mouse gene deleted in the cre-expressing tissues.Heterozygous:Heterozygous mice for this allele are viable and fertile, and do not display any pathological phenotype. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Oulu, Oulu, Finland |
| Animals used for archiving | heterozygous C57BL/6, wild-type C57BL/6NCrl |
| Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Tetralogy of Fallot / Orphanet_3303
- Milroy disease / Orphanet_79452
Literature references
- Deletion of vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos.;Haiko Paula, Makinen Taija, Keskitalo Salla, Taipale Jussi, Karkkainen Marika J, Baldwin Megan E, Stacker Steven A, Achen Marc G, Alitalo Kari, ;2008;Molecular and cellular biology;28;4843-50; 18519586
- VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling.;Tammela Tuomas, Zarkada Georgia, Nurmi Harri, Jakobsson Lars, Heinolainen Krista, Tvorogov Denis, Zheng Wei, Franco Claudio A, Murtomäki Aino, Aranda Evelyn, Miura Naoyuki, Ylä-Herttuala Seppo, Fruttiger Marcus, Mäkinen Taija, Eichmann Anne, Pollard Jeffrey W, Gerhardt Holger, Alitalo Kari, ;2011;Nature cell biology;13;1202-13; 21909098
- VEGFR3 does not sustain retinal angiogenesis without VEGFR2.;Zarkada Georgia, Heinolainen Krista, Makinen Taija, Kubota Yoshiaki, Alitalo Kari, ;2015;Proceedings of the National Academy of Sciences of the United States of America;112;761-6; 25561555