STOCK Tg(Ttr-NR0B2)1Ital/Flmg
Status | Available to order |
EMMA ID | EM:09491 |
International strain name | STOCK Tg(Ttr-NR0B2)1Ital/Flmg |
Alternative name | B6.CBA-Tg(Ttr-NR0B2)1Ital/Flmg |
Strain type | Transgenic Strains |
Allele/Transgene symbol | Tg(Ttr-NR0B2)1Ital |
Gene/Transgene symbol | Tg(Ttr-NR0B2)1Ital |
Information from provider
Provider | Iannis Talianidis |
Provider affiliation | BSRC Alexander Fleming |
Genetic information | The transgenic construct expresses human NR0B2 (former SHP) (HA-Tag) flagged under the mouse Ttr promoter. Hepatic SHP expression in this transgenic line is 7-fold above endogenous levels. |
Phenotypic information | Homozygous:The livers of transgenic animals are visibly enlarged and pale in color. Extensive lipid accumulation is detected in SHP-expressing hepatocytes. Hepatic triglyceride levels are markedly increased and the concentration of hepatic bile acids is significantly decreased. Major defects in Tg-SHP mice occur in bile acid synthesis, lipogenesis, de novo cholesterol biosynthesis and absorption pathways.Heterozygous:NOT EXAMINED |
References |
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Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
Animals used for archiving | heterozygous C57BL/6.CBA, wild-type (C57BL/6 x CBA)F1 |
Stage of embryos | 2-cell |
Literature references
- Regulation of hepatic metabolic pathways by the orphan nuclear receptor SHP.;Boulias Konstantinos, Katrakili Nitsa, Bamberg Krister, Underhill Peter, Greenfield Andy, Talianidis Iannis, ;2005;The EMBO journal;24;2624-33; 15973435
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