B6.Cg-Tg(RasE)290Biat/Biat
| Status | Available to order |
| EMMA ID | EM:09501 |
| International strain name | B6.Cg-Tg(RasE)290Biat/Biat |
| Alternative name | B6;D2-Tg(RasE)290Biat |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(RasE)290Biat |
| Gene/Transgene symbol | Tg(RasE)290Biat |
Information from provider
| Provider | Robert Eferl |
| Provider affiliation | Institute for Cancer Research (ICR), Medical University Vienna (MUV) |
| Additional owner | Prof. Thomas Ruelicke, Vetmeduni Vienna, Vienna, Austria |
| Genetic information | Transgenic line produced by pronucleus injection of a BAC transgene |
| Phenotypic information | Homozygous:The mice have no phenotype because there is no transgene expression per se. Three oncogenic H-RasV12 effector mutants are expressed in a stochastic manner when cre recombinase is induced. This will cause oncogenic transformation of cre-expressing cells and tumor formation.Heterozygous:no phenotype |
| Breeding history | Transgenic line was intercrossed several times and then backcrossed for 6 generations into C57BL/6J. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Veterinary Medicine, Vienna, Austria |
Literature references
- A mouse model to identify cooperating signaling pathways in cancer.;Musteanu Monica, Blaas Leander, Zenz Rainer, Svinka Jasmin, Hoffmann Thomas, Grabner Beatrice, Schramek Daniel, Kantner Hans-Peter, Müller Mathias, Kolbe Thomas, Rülicke Thomas, Moriggl Richard, Kenner Lukas, Stoiber Dagmar, Penninger Josef Martin, Popper Helmut, Casanova Emilio, Eferl Robert, ;2012;Nature methods;9;897-900; 22863881