B6;CBACa-Tg(MMTV-VEGFB*)1Sjh/H
| Status | Available to order |
| EMMA ID | EM:09695 |
| International strain name | B6;CBACa-Tg(MMTV-VEGFB*)1Sjh/H |
| Alternative name | C57BL/6J x CBA/Ca |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(MMTV-VEGFB*)1Sjh |
| Gene/Transgene symbol | Tg(MMTV-VEGFB*)1Sjh |
Information from provider
| Provider | David Bates |
| Provider affiliation | Cancer Biology, Division of Cancer and Stem cells, University of Nottingham |
| Genetic information | The genetic background of the embryos used for transgene injection is C57BL/6J x CBA/Ca. |
| Phenotypic information | Homozygous:Unknown.Heterozygous:Transgenic females are relatively infertile. They have poor milk production in order to wean pups, thus the transgenic line is maintained in males. |
| Breeding history | Sib-mated for >10 generations. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | heterozygous C57BL/6 |
| Breeding at archiving centre | Cross to C57BL/6 |
Literature references
- Mammary alveolar development during lactation is inhibited by the endogenous antiangiogenic growth factor isoform, VEGF165b.;Qiu Yan, Bevan Heather, Weeraperuma Sudath, Wratting Daniel, Murphy David, Neal Christopher R, Bates David O, Harper Steven J, ;2008;FASEB journal : official publication of the Federation of American Societies for Experimental Biology;22;1104-12; 18032632
- Ovarian VEGF(165)b expression regulates follicular development, corpus luteum function and fertility.;Qiu Y, Seager M, Osman A, Castle-Miller J, Bevan H, Tortonese D J, Murphy D, Harper S J, Fraser H M, Donaldson L F, Bates D O, ;2012;Reproduction (Cambridge, England);143;501-11; 22232745