B6;129P2-Chd4tm1.1Bh/H
| Status | Available to order |
| EMMA ID | EM:09714 |
| International strain name | B6;129P2-Chd4tm1.1Bh/H |
| Alternative name | CHD4 Flox |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Chd4tm1.1Bh, |
| Gene/Transgene symbol | Chd4 |
Information from provider
| Provider | Brian Hendrich |
| Provider affiliation | Wellcome Trust - MRC Stem Cell Institute, University of Cambridge |
| Genetic information | Conditional allele of Chd4. |
| Phenotypic information | Homozygous:Homozygous floxed has no phenotype. Homozygous deletion is lethal at 3.5 dpc.Heterozygous:Heterozygous floxed or heterozygous deletion has no phenotype. |
| Breeding history | Created from 129/Ola ES cell line, outcrossed to C57BL/6 once, then maintained as sib matings. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- Constraint of gene expression by the chromatin remodelling protein CHD4 facilitates lineage specification.;O'Shaughnessy-Kirwan Aoife, Signolet Jason, Costello Ita, Gharbi Sarah, Hendrich Brian, ;2015;Development (Cambridge, England);142;2586-97; 26116663