STOCK Tmprss4tm1.2Hum/Ph
Status | Available to order |
EMMA ID | EM:09860 |
International strain name | STOCK Tmprss4tm1.2Hum/Ph |
Alternative name | Tmprss4 -/- |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Tmprss4tm1.2Hum, |
Gene/Transgene symbol | Tmprss4 |
Information from provider
Provider | Edith Hummler |
Provider affiliation | Département de Pharmacologie et de Toxicologie, University of Lausanne |
Genetic information | Homologous recombination in mouse embryonic stem cells was performed to place loxP sites around exons 8 and 9 of the Tmprss4 gene locus containing the histidine and the aspartate of the catalytic triad. Southern blot analyses confirmed correct targeting of ES cell. Tmprss4loxneo/+ mice were mated with Cre- or Flp-deleter mouse strains, and floxed heterozygous mutant and knockout mice were obtained. |
Phenotypic information | Homozygous:Tmprss4 knockout mice do not show an obvious phenotype and are viable and fertile.Heterozygous:Tmprss4 heterozygous mice do not show an obvious phenotype and are viable and fertile. |
Breeding history | The line was maintained by crossing Tmprss4 +/- with Tmprss4 +/-. |
References |
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Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | Institute of Molecular Genetics, Prague, Czech Republic |
Animals used for archiving | heterozygous 0 |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal recessive cerebral atrophy / Orphanet_363969
Literature references
- Epithelial Sodium Channel-Mediated Sodium Transport Is Not Dependent on the Membrane-Bound Serine Protease CAP2/Tmprss4.;Keppner Anna, Andreasen Ditte, Mérillat Anne-Marie, Bapst Julie, Ansermet Camille, Wang Qing, Maillard Marc, Malsure Sumedha, Nobile Antoine, Hummler Edith, ;2015;PloS one;10;e0135224; 26309024
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