STOCK Lipatm1a(EUCOMM)Hmgu/Biat
| Status | Available to order |
| EMMA ID | EM:10357 |
| International strain name | STOCK Lipatm1a(EUCOMM)Hmgu/Biat |
| Alternative name | Stock Lipa |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Lipatm1a(EUCOMM)Hmgu, |
| Gene/Transgene symbol | Lipa |
Information from provider
| Provider | Dagmar Kratky |
| Provider affiliation | Institute of Molecular Biology and Biochemistry Center for Molecular Medicine, Medical University of Graz |
| Genetic information | Mouse line originates from EUCOMM clone HEPD0960_2_H11 injected into BALB/c blastocysts |
| Phenotypic information | Homozygous:unknownHeterozygous:unknown |
| References |
|
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | University of Veterinary Medicine, Vienna, Austria |
| Animals used for archiving | heterozygous C57BL/6N |
| Breeding at archiving centre | INFRAFRONTIER-I3 WP8 line produced by ES cell injection at Vetmed. |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Wolman disease / Orphanet_75233
- Cholesteryl ester storage disease / Orphanet_75234
Literature references
- Hepatocyte-specific lysosomal acid lipase deficiency protects mice from diet-induced obesity but promotes hepatic inflammation.;Leopold Christina, Duta-Mare Madalina, Sachdev Vinay, Goeritzer Madeleine, Maresch Lisa Katharina, Kolb Dagmar, Reicher Helga, Wagner Bettina, Stojakovic Tatjana, Ruelicke Thomas, Haemmerle Guenter, Hoefler Gerald, Sattler Wolfgang, Kratky Dagmar, ;2019;Biochimica et biophysica acta. Molecular and cell biology of lipids;1864;500-511; 30639734