STOCK Dll1tm11.1Gos/Biat
Status | Available to order |
EMMA ID | EM:10390 |
International strain name | STOCK Dll1tm11.1Gos/Biat |
Alternative name | Dll1EGF3m |
Strain type | Targeted Mutant Strains : Knock-in |
Allele/Transgene symbol | Dll1tm11.1Gos, |
Gene/Transgene symbol | Dll1 |
Information from provider
Provider | Achim Gossler |
Provider affiliation | Medizinische Hochschule Hannover |
Genetic information | Knock in of a Dll1 mini gene with mutated EGF3 into Dll1 locus. |
Phenotypic information | Homozygous:EGF3m lethal E18.5 massive skeletal defects.Heterozygous:heterozygous normal |
Breeding history | From isogenic 129ImJ three generations on CD1, then kept on this mixed background. |
References |
|
Homozygous fertile | no |
Homozygous viable | no |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | University of Veterinary Medicine, Vienna, Austria |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Alobar holoprosencephaly / Orphanet_93925
- Autosomal dominant non-syndromic intellectual disability / Orphanet_178469
- Midline interhemispheric variant of holoprosencephaly / Orphanet_93926
- Microform holoprosencephaly / Orphanet_280200
- Septopreoptic holoprosencephaly / Orphanet_280195
- Semilobar holoprosencephaly / Orphanet_220386
- Lobar holoprosencephaly / Orphanet_93924
Literature references
- Context-Dependent Sensitivity to Mutations Disrupting the Structural Integrity of Individual EGF Repeats in the Mouse Notch Ligand DLL1.;Schuster-Gossler Karin, Cordes Ralf, Müller Julia, Geffers Insa, Delany-Heiken Patricia, Taft Manuel, Preller Matthias, Gossler Achim, ;2016;Genetics;202;1119-33; 26801181
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