STOCK Dll1tm14.1Gos/Kctt
| Status | Available to order |
| EMMA ID | EM:10393 |
| International strain name | STOCK Dll1tm14.1Gos/Kctt |
| Alternative name | Dll1EGF6m |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Dll1tm14.1Gos, |
| Gene/Transgene symbol | Dll1 |
Information from provider
| Provider | Achim Gossler |
| Provider affiliation | Medizinische Hochschule Hannover |
| Genetic information | Knock in of a Dll1 mini gene with mutated EGF6 into the Dll1 locus. |
| Phenotypic information | Homozygous:EGF6m viable normal.Heterozygous:Heterozygous normal. |
| Breeding history | From isogenic 129ImJ three generations on CD1, then kept on this mixed background. |
| References |
|
| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Karolinska Institutet, Stockholm, Sweden |
| Animals used for archiving | homozygous 0 |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Alobar holoprosencephaly / Orphanet_93925
- Autosomal dominant non-syndromic intellectual disability / Orphanet_178469
- Midline interhemispheric variant of holoprosencephaly / Orphanet_93926
- Microform holoprosencephaly / Orphanet_280200
- Septopreoptic holoprosencephaly / Orphanet_280195
- Semilobar holoprosencephaly / Orphanet_220386
- Lobar holoprosencephaly / Orphanet_93924
Literature references
- Context-Dependent Sensitivity to Mutations Disrupting the Structural Integrity of Individual EGF Repeats in the Mouse Notch Ligand DLL1.;Schuster-Gossler Karin, Cordes Ralf, Müller Julia, Geffers Insa, Delany-Heiken Patricia, Taft Manuel, Preller Matthias, Gossler Achim, ;2016;Genetics;202;1119-33; 26801181