STOCK Tubb5tm2.1Dak/Biat
| Status | Available to order |
| EMMA ID | EM:10543 |
| International strain name | STOCK Tubb5tm2.1Dak/Biat |
| Alternative name | Tubb5 KO / Freddie |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Tubb5tm2.1Dak, |
| Gene/Transgene symbol | Tubb5 |
Information from provider
| Provider | David Keays |
| Provider affiliation | Keays Group, Institute of Molecular Pathology |
| Genetic information | The terminal exon of the Tubb5 gene (exon 4) was flanked with loxP sites. |
| Phenotypic information | Homozygous:When employing nestin promoter-driven cre recombinase, homozygous animals are not viable.Heterozygous:When employing nestin promoter-driven cre recombinase, heterozygous animals are presented with a large reduction in total brain as well as cortical volume. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | yes |
Information from EMMA
| Archiving centre | University of Veterinary Medicine, Vienna, Austria |
| Animals used for archiving | homozygous C57BL/6 |
Literature references
- Mutations in the murine homologue of TUBB5 cause microcephaly by perturbing cell cycle progression and inducing p53-associated apoptosis.;Breuss Martin, Fritz Tanja, Gstrein Thomas, Chan Kelvin, Ushakova Lyubov, Yu Nuo, Vonberg Frederick W, Werner Barbara, Elling Ulrich, Keays David A, ;2016;Development (Cambridge, England);143;1126-33; 26903504