STOCK Ightm10.1Cog/Orl

Status

Available to order

EMMA IDEM:11092
International strain nameSTOCK Ightm10.1Cog/Orl
Alternative nameDelta2-3'RR-deficient mice
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolIghtm10.1Cog,
Gene/Transgene symbolIgh

Information from provider

ProviderYves Denizot
Provider affiliationUMR CNRS 6101
Genetic informationThe IgH 3’ regulatory region (3’RR) controls class switch recombination (CSR) and somatic hypermutation (SHM) in B cells. The mouse 3’RR contains four enhancer elements with hs1,2 flanked by inverted repeated sequences and the center of a 25-kb palindrome bounded by two hs3 enhancer inverted copies (hs3a and hs3b); hs4 lies downstream of the palindrome. We generated and analysed mice without the left part of the 3'RR (hs3a-IRIS-hs1,2): Delta2-3'RR-deficient mice
Phenotypic informationHomozygous:
Decrease of somatic hypermutation rate in VH gene. Decrease of class switch recombination. Decrease in circulating Ig levels. Decrease of germinal transcription of IgH genes.

Heterozygous:
---
References
  • Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3' regulatory region.;Saintamand Alexis, Vincent-Fabert Christelle, Garot Armand, Rouaud Pauline, Oruc Zeliha, Magnone Virginie, Cogné Michel, Denizot Yves, ;2016;Nature communications;7;10730; 26883548
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivinghomozygous 129

Literature references

  • Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3' regulatory region.;Saintamand Alexis, Vincent-Fabert Christelle, Garot Armand, Rouaud Pauline, Oruc Zeliha, Magnone Virginie, Cogné Michel, Denizot Yves, ;2016;Nature communications;7;10730; 26883548

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).