- decreased hematocrit / MGI
- increased neutrophil cell number / MGI
- abnormal liver physiology / MGI
- increased circulating alanine transaminase level / MGI
- increased liver weight / MGI
- decreased spleen weight / MGI
- decreased thymus weight / MGI
- decreased lymphocyte cell number / MGI
- increased circulating aspartate transaminase level / MGI
- abnormal hemoglobin content / MGI
- increased hemoglobin content / MGI
- increased physiological sensitivity to xenobiotic / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- abnormal xenobiotic pharmacokinetics / MGI
- decreased sensitivity to xenobiotic induced morbidity/mortality / MGI
- increased susceptibility to weight loss / MGI
- decreased leukocyte cell number / MGI
- enlarged liver / MGI
- small spleen / MGI
- small thymus / MGI
- abnormal iridocorneal angle / MGI
- hypoplastic trabecular meshwork / MGI
- abnormal canal of Schlemm morphology / MGI
- decreased incidence of tumors by chemical induction / MGI
- absent Schlemm's canal / MGI
- abnormal trabecular meshwork morphology / MGI
- anterior iris synechia / MGI
B6.Cg-Cyp1a1tm1.1Dwn Cyp1a2tm1Dwn Cyp1b1tm1Gonz/H
Status | Available to order |
EMMA ID | EM:11097 |
International strain name | B6.Cg-Cyp1a1tm1.1Dwn Cyp1a2tm1Dwn Cyp1b1tm1Gonz/H |
Alternative name | Triple Cyp |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Cyp1b1tm1Gonz, |
Gene/Transgene symbol | Cyp1b1 |
Information from provider
Provider | Brigitta Stockinger |
Provider affiliation | Mill Hill Laboratory, The Francis Crick Institute |
Genetic information | Stock that is homozygous for three knock-outs: Cyp1a1tm1.1Dwn, Cyp1a2tm1Dwn and Cyp1b1tm1Gonz. Stock described as being fully backcrossed to C57BL/6 (initially with C57BL/6J, but latterly with two generations of backcrossing to C57BL/6Nimr). |
Phenotypic information | Homozygous:Mice homozygous for all three knock-out alleles at Cyp1a1, Cyp1a2 and Cyp1b1 have an increased risk of death before embryonic day 11, and exhibit (with reduced penetrance) hydrocephalus, hermaphroditism and cystic ovaries. They also show slower weight gain, but are also prone to develop spontaneous obesity. The activity of many genes has been shown to be perturbed including those involved in: lipid, steroid and cholesterol biosynthesis and metabolism; metal-ion binding; nucleosome and chromatin assembly (see Dragin et al., 2008, Mol Pharmacol 73, (6), 1844-56).Heterozygous:Not known; probably no overt phenotype. |
Breeding history | Stock described as being fully backcrossed to C57BL/6 (initially with C57BL/6J, but latterly with two generations of backcrossing to C57BL/6Nimr). Strain has been bred to homozygosity. |
References |
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Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Animals used for archiving | homozygous C57BL/6 |
Breeding at archiving centre | C57BL/6 background |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Peters anomaly / Orphanet_708
- Congenital glaucoma / Orphanet_98976
MGI phenotypes (allele matching)
Literature references
- Feedback control of AHR signalling regulates intestinal immunity.;Schiering Chris, Wincent Emma, Metidji Amina, Iseppon Andrea, Li Ying, Potocnik Alexandre J, Omenetti Sara, Henderson Colin J, Wolf C Roland, Nebert Daniel W, Stockinger Brigitta, ;2017;Nature;542;242-245; 28146477
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