B6;129P2-Wnt4tm2(EGFP/cre)Svo/Oulu
| Status | Available to order |
| EMMA ID | EM:10011 |
| International strain name | B6;129P2-Wnt4tm2(EGFP/cre)Svo/Oulu |
| Alternative name | Wnt-4-Cre |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Wnt4tm2(EGFP/cre)Svo, |
| Gene/Transgene symbol | Wnt4 |
Information from provider
| Provider | Jingdong Shan |
| Provider affiliation | Department of Biochemistry and Molecular Medicine, University of Oulu |
| Additional owner | Dr. Seppo Vainio, University of Oulu, Oulu, Finland |
| Genetic information | Targeted construct in 129/Ola ES cells replaces the Wnt4 gene after the promoter with cre recombinase. |
| Phenotypic information | Homozygous:Wnt4-cre homozygotes have the same phenotype as Wnt4 knockouts. Kidney malformation and female to male sex reversal. Homozygotes die few days after birth.Heterozygous:Heterozygous mice have no reported phenotypes. |
| Breeding history | Targeted mutation was directly maintained on a C57BL/6 background. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Oulu, Oulu, Finland |
| Animals used for archiving | heterozygous C57BL/6JOlaHsd, wild-type C57BL/6NCrl |
| Stage of embryos | 2-cell |
Literature references
- Generation of an allele to inactivate Wnt4 gene function conditionally in the mouse.;Shan Jingdong, Jokela Tiina, Peltoketo Hellevi, Vainio Seppo, ;2009;Genesis (New York, N.Y. : 2000);47;782-8; 19830824
- Mapping of the fate of cell lineages generated from cells that express the Wnt4 gene by time-lapse during kidney development.;Shan Jingdong, Jokela Tiina, Skovorodkin Ilya, Vainio Seppo, ;2010;Differentiation; research in biological diversity;79;57-64; 19740593