NMRI.129-Apaf1Gt(IRESBetageo)XIX18Pgr/Cnrm

Status

Available to order

EMMA IDEM:01017
International strain nameNMRI.129-Apaf1Gt(IRESBetageo)XIX18Pgr/Cnrm
Alternative nameApaf-1/XIX-18
Strain typeGene-trap
Allele/Transgene symbolApaf1Gt(IRESBetageo)XIX18Pgr,
Gene/Transgene symbolApaf1

Information from provider

ProviderPeter Gruss
Provider affiliationMax Planck Inst. Biophysical Chemistry
Genetic informationIRESpGEO insertion in the Apaf1 gene at codon encoding amino-acid 1018 of the APAF1 protein.
Phenotypic informationHeterozygous mice: normal size, healthy. Homozygous mice: lethal at E16.5: cranio-facial alterations, persistence of inter-digital webs, abnormal eye development. Apaf1 is a candidate gene for Noonan syndrome.
Breeding historyMutants were backcrossed with wild-type NMRI to 6 generations.
References
  • Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.;Cecconi F, Alvarez-Bolado G, Meyer B I, Roth K A, Gruss P, ;1998;Cell;94;727-37; 9753320

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI allele-associated human disease models

MGI phenotypes (allele matching)
  • motor neuron degeneration / MGI
  • abnormal neuron morphology / MGI
  • decreased neuron apoptosis / MGI
  • absent neurocranium / MGI
  • absent vomer bone / MGI
  • absent ethmoid bone / MGI
  • impaired ossification of basisphenoid bone / MGI
  • midline facial cleft / MGI
  • interdigital webbing / MGI
  • abnormal embryonic neuroepithelial layer differentiation / MGI
  • abnormal cortical marginal zone morphology / MGI
  • choroid plexus hyperplasia / MGI
  • diencephalon hyperplasia / MGI
  • hypothalamus hyperplasia / MGI
  • midbrain hyperplasia / MGI
  • abnormal brain development / MGI
  • exencephaly / MGI
  • abnormal folding of telencephalic vesicles / MGI
  • small embryonic telencephalon / MGI
  • persistence of hyaloid vascular system / MGI
  • small lens / MGI
  • abnormal lens polarity / MGI
  • retina hyperplasia / MGI
  • hydroencephaly / MGI
  • abnormal embryonic tissue morphology / MGI
  • abnormal craniofacial bone morphology / MGI
  • abnormal brain morphology / MGI
  • nervous system phenotype / MGI
  • abnormal neuron physiology / MGI
  • persistence of medial edge epithelium during palatal shelf fusion / MGI
  • lethality throughout fetal growth and development, complete penetrance / MGI
  • decreased fibroblast apoptosis / MGI
  • increased neuron apoptosis / MGI
  • abnormal apoptosis / MGI

Literature references

  • Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.;Cecconi F, Alvarez-Bolado G, Meyer B I, Roth K A, Gruss P, ;1998;Cell;94;727-37; 9753320

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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