B6.129P2-Dp(16Lipi-Zbtb21)1TybEmcf/TybH
| Status | Available to order |
| EMMA ID | EM:10557 |
| International strain name | B6.129P2-Dp(16Lipi-Zbtb21)1TybEmcf/TybH |
| Alternative name | Dp1Tyb |
| Strain type | Targeted Mutant Strains : Other targeted |
| Allele/Transgene symbol | Dp(16Lipi-Zbtb21)1TybEmcf, |
| Gene/Transgene symbol | Dp(16Lipi-Zbtb21)1TybEmcf |
Information from provider
| Provider | Victor Tybulewicz |
| Provider affiliation | Francis Crick Institute |
| Additional owner | Elizabeth Fisher, University College London, UK |
| Genetic information | Duplication of 23Mb of Mmu16 from Lipi to Zbtb21 |
| Phenotypic information | Homozygous:Heterozygous:Mice have congenital heart defects, locomotor dysfunction, electrophysiological changes in hippocampus and learning defects. |
| Breeding history | Mutant allele was established in HM1 ES cells, then transmitted through the germline and maintained by breeding to C57BL/6J. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | heterozygous C57BL/6J |
| Breeding at archiving centre | Backcrossed 6 times to C57BL/6J |
Disease and phenotype information
MGI allele-associated human disease models
Literature references
- Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel.;Lana-Elola Eva, Watson-Scales Sheona, Slender Amy, Gibbins Dorota, Martineau Alexandrine, Douglas Charlotte, Mohun Timothy, Fisher Elizabeth Mc, Tybulewicz Victor Lj, ;2016;eLife;5;1165-1186; 26765563
- Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of Down syndrome-related phenotypes.;Lana-Elola Eva, Cater Heather, Watson-Scales Sheona, Greenaway Simon, Müller-Winkler Jennifer, Gibbins Dorota, Nemes Mihaela, Slender Amy, Hough Tertius, Keskivali-Bond Piia, Scudamore Cheryl L, Herbert Eleanor, Banks Gareth T, Mobbs Helene, Canonica Tara, Tosh Justin, Noy Suzanna, Llorian Miriam, Nolan Patrick M, Griffin Julian L, Good Mark, Simon Michelle, Mallon Ann-Marie, Wells Sara, Fisher Elizabeth M C, Tybulewicz Victor L J, ;2021;Disease models & mechanisms;14;; 34477842
- Rodent models in Down syndrome research: impact and future opportunities.;Herault Yann, Delabar Jean M, Fisher Elizabeth M C, Tybulewicz Victor L J, Yu Eugene, Brault Veronique, ;2017;Disease models & mechanisms;10;; 28993310