C57BL/6-Atm1Brd Hnrnprtm1a(EUCOMM)Wtsi/Flmg
| Status | Available to order |
| EMMA ID | EM:10602 |
| International strain name | C57BL/6-Atm1Brd Hnrnprtm1a(EUCOMM)Wtsi/Flmg |
| Alternative name | B6-Hnrnpr |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Hnrnprtm1a(EUCOMM)Wtsi, |
| Gene/Transgene symbol | Hnrnpr |
Information from provider
| Provider | Michael Sendtner |
| Provider affiliation | Institute for Clinical Neurobiology, University of Würzburg |
| Genetic information | The L1L2_Bact_P cassette was inserted at position 136315880 of chromosome 4 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 136316682. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other EUCOMM/KOMP alleles can be found here. |
| Phenotypic information | Homozygous:Not characterized yetHeterozygous:Not characterized yet |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
| Animals used for archiving | heterozygous C57BL/6, wild-type C57BL/6 |
| Stage of embryos | Morula |
Literature references
- Loss of full-length hnRNP R isoform impairs DNA damage response in motoneurons by inhibiting Yb1 recruitment to chromatin.;Ghanawi Hanaa, Hennlein Luisa, Zare Abdolhossein, Bader Jakob, Salehi Saeede, Hornburg Daniel, Ji Changhe, Sivadasan Rajeeve, Drepper Carsten, Meissner Felix, Mann Matthias, Jablonka Sibylle, Briese Michael, Sendtner Michael, ;2021;Nucleic acids research;49;12284-12305; 34850154