STOCK Tg(Sox2-cre/ERT2)1Skn/Cnrm
| Status | Available to order |
| EMMA ID | EM:10853 |
| International strain name | STOCK Tg(Sox2-cre/ERT2)1Skn/Cnrm |
| Alternative name | Sox2CreERT2 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Sox2-cre/ERT2)1Skn, |
| Gene/Transgene symbol | Tg(Sox2-cre/ERT2)1Skn |
Information from provider
| Provider | Silvia Nicolis |
| Provider affiliation | Department of Biotechnology and Biosciences, University of Milano-Bicocca |
| Genetic information | The telencephalic promoter-enhancer of the Sox2 gene (Zappone et al., Development 2000, 127:2367-2382) is cloned upstream to the CreERT2 gene, encoding the tamoxifen-inducible Cre recombinase (see Favaro et al., Nature Neuroscience 2009,12:1248-1256). |
| Phenotypic information | Homozygous:No phenotypeHeterozygous:No phenotype |
| Breeding history | The transgenic line was generated by pronuclear injection of C57BL/6 x DBA oocytes, and the transgenic line was maintained by breeding of heterozygous carriers to non-carrier cousins. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh.;Favaro Rebecca, Valotta Menella, Ferri Anna L M, Latorre Elisa, Mariani Jessica, Giachino Claudio, Lancini Cesare, Tosetti Valentina, Ottolenghi Sergio, Taylor Verdon, Nicolis Silvia K, ;2009;Nature neuroscience;12;1248-56; 19734891