C3HeB/FeJ-Scube3m1Mhda/Ieg

Status

Available to order

EMMA IDEM:10872
International strain nameC3HeB/FeJ-Scube3m1Mhda/Ieg
Alternative nameScube3-KTA041 = Scube3N294K/N294K
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolScube3m1Mhda,
Gene/Transgene symbolScube3

Information from provider

ProviderMartin Hrabe de Angelis
Provider affiliationInstitute of Experimental Genetics, Helmholtz Zentrum München
Genetic informationA C to A transversion at nucleotide position 882 in exon 8 of Scube3 leads to an asparagine to lysine exchange at protein position 294 (N294K).
Phenotypic informationHomozygous:
Morphological abnormalities of the skeleton, alterations of parameters relevant for bone metabolism, changes in renal function and hearing impairments.

Heterozygous:
No clear phenotype.
References
  • The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations.;Fuchs Helmut, Sabrautzki Sibylle, Przemeck Gerhard K H, Leuchtenberger Stefanie, Lorenz-Depiereux Bettina, Becker Lore, Rathkolb Birgit, Horsch Marion, Garrett Lillian, Östereicher Manuela A, Hans Wolfgang, Abe Koichiro, Sagawa Nobuho, Rozman Jan, Vargas-Panesso Ingrid L, Sandholzer Michael, Lisse Thomas S, Adler Thure, Aguilar-Pimentel Juan Antonio, Calzada-Wack Julia, Ehrhard Nicole, Elvert Ralf, Gau Christine, Hölter Sabine M, Micklich Katja, Moreth Kristin, Prehn Cornelia, Puk Oliver, Racz Ildiko, Stoeger Claudia, Vernaleken Alexandra, Michel Dian, Diener Susanne, Wieland Thomas, Adamski Jerzy, Bekeredjian Raffi, Busch Dirk H, Favor John, Graw Jochen, Klingenspor Martin, Lengger Christoph, Maier Holger, Neff Frauke, Ollert Markus, Stoeger Tobias, Yildirim Ali Önder, Strom Tim M, Zimmer Andreas, Wolf Eckhard, Wurst Wolfgang, Klopstock Thomas, Beckers Johannes, Gailus-Durner Valerie, Hrabé de Angelis Martin, ;2016;G3 (Bethesda, Md.);6;4035-4046; 27815347
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Disease and phenotype information

MGI phenotypes (allele matching)
  • abnormal inner ear morphology / MGI
  • abnormal malleus morphology / MGI
  • abnormal middle ear morphology / MGI
  • decreased bone mineral density / MGI
  • rib fusion / MGI
  • increased circulating calcium level / MGI
  • decreased circulating phosphate level / MGI
  • thin ventricular wall / MGI
  • abnormal interventricular septum morphology / MGI
  • kinked tail / MGI
  • short tail / MGI
  • decreased body size / MGI
  • abnormal anxiety-related response / MGI
  • hypoactivity / MGI
  • abnormal posture / MGI
  • polyuria / MGI
  • abnormal digit morphology / MGI
  • decreased circulating triglyceride level / MGI
  • decreased circulating free fatty acid level / MGI
  • decreased vertical activity / MGI
  • decreased urine protein level / MGI
  • abnormal thoracic vertebrae morphology / MGI
  • abnormal lumbar vertebrae morphology / MGI
  • abnormal metatarsal bone morphology / MGI
  • abnormal metacarpal bone morphology / MGI
  • short femur / MGI
  • decreased circulating glycerol level / MGI
  • decreased urine glucose level / MGI
  • abnormal heart left ventricle morphology / MGI
  • decreased lean body mass / MGI
  • abnormal pectoral girdle bone morphology / MGI
  • abnormal vertebral pedicle morphology / MGI
  • conductive hearing loss / MGI
  • increased bone resorption / MGI
  • abnormal tarsal bone morphology / MGI
  • abnormal middle ear ossicle morphology / MGI
  • decreased circulating cholesterol level / MGI
  • abnormal temporal bone morphology / MGI
  • improved glucose tolerance / MGI
  • decreased circulating serum albumin level / MGI
  • abnormal food intake / MGI
  • abnormal body composition / MGI
  • decreased urine albumin level / MGI
  • increased circulating creatinine level / MGI
  • decreased circulating glucose level / MGI
  • increased blood urea nitrogen level / MGI
  • decreased circulating total protein level / MGI
  • decreased pulmonary respiratory rate / MGI
  • abnormal enzyme/coenzyme activity / MGI
  • increased circulating potassium level / MGI
  • abnormal bone ossification / MGI
  • fused phalanges / MGI
  • increased blood uric acid level / MGI
  • decreased grip strength / MGI
  • decreased bone mineral content / MGI
  • abnormal malleus head morphology / MGI
  • prolonged QRS complex duration / MGI
  • decreased urine uric acid level / MGI
  • decreased urine creatinine level / MGI
  • increased alkaline phosphatase activity / MGI
  • increased fluid intake / MGI
  • increased or absent threshold for auditory brainstem response / MGI
  • abnormal renal filtration / MGI
  • decreased body fat mass / MGI
  • small incus / MGI
  • small middle ear ossicles / MGI

Literature references

  • The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations.;Fuchs Helmut, Sabrautzki Sibylle, Przemeck Gerhard K H, Leuchtenberger Stefanie, Lorenz-Depiereux Bettina, Becker Lore, Rathkolb Birgit, Horsch Marion, Garrett Lillian, Östereicher Manuela A, Hans Wolfgang, Abe Koichiro, Sagawa Nobuho, Rozman Jan, Vargas-Panesso Ingrid L, Sandholzer Michael, Lisse Thomas S, Adler Thure, Aguilar-Pimentel Juan Antonio, Calzada-Wack Julia, Ehrhard Nicole, Elvert Ralf, Gau Christine, Hölter Sabine M, Micklich Katja, Moreth Kristin, Prehn Cornelia, Puk Oliver, Racz Ildiko, Stoeger Claudia, Vernaleken Alexandra, Michel Dian, Diener Susanne, Wieland Thomas, Adamski Jerzy, Bekeredjian Raffi, Busch Dirk H, Favor John, Graw Jochen, Klingenspor Martin, Lengger Christoph, Maier Holger, Neff Frauke, Ollert Markus, Stoeger Tobias, Yildirim Ali Önder, Strom Tim M, Zimmer Andreas, Wolf Eckhard, Wurst Wolfgang, Klopstock Thomas, Beckers Johannes, Gailus-Durner Valerie, Hrabé de Angelis Martin, ;2016;G3 (Bethesda, Md.);6;4035-4046; 27815347

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).