- decreased level of surface class I molecules / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- decreased IgG level / MGI
- abnormal pancreas morphology / MGI
- decreased susceptibility to bacterial infection / MGI
- increased IgM level / MGI
- decreased susceptibility to autoimmune diabetes / MGI
- decreased circulating serum albumin level / MGI
- increased T-helper 1 cell number / MGI
- abnormal interleukin level / MGI
- abnormal tumor necrosis factor level / MGI
- increased susceptibility to infection induced morbidity/mortality / MGI
- absent CD8-positive, alpha-beta T cells / MGI
- abnormal pancreatic beta cell morphology / MGI
- abnormal T cell number / MGI
- insulitis / MGI
- abnormal neuron proliferation / MGI
- abnormal immune system morphology / MGI
- abnormal spleen morphology / MGI
- abnormal immune system cell morphology / MGI
- postnatal growth retardation / MGI
- abnormal immune system physiology / MGI
- reduced fertility / MGI
- abnormal spleen periarteriolar lymphoid sheath morphology / MGI
- abnormal spleen marginal zone morphology / MGI
- abnormal CD4-positive, alpha beta T cell morphology / MGI
- abnormal T cell physiology / MGI
- abnormal B cell physiology / MGI
- abnormal immune system organ morphology / MGI
- abnormal cytokine secretion / MGI
- decreased susceptibility to parasitic infection / MGI
- increased susceptibility to parasitic infection / MGI
- abnormal CD4-positive, alpha-beta T cell physiology / MGI
- increased CD4-positive, alpha beta T cell number / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- increased CD8-positive, alpha-beta T cell number / MGI
- abnormal spleen B cell follicle morphology / MGI
- absent spleen germinal center / MGI
- decreased IgG1 level / MGI
- abnormal lymph node cell ratio / MGI
STOCK B2mtm1Unc H2-Ab1tm1Doi Foxp3tm Tg(HLA-A/H2-D/B2M)1Bpe Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dma/Orl
Status | Available to order |
EMMA ID | EM:10977 |
International strain name | STOCK B2mtm1Unc H2-Ab1tm1Doi Foxp3tm Tg(HLA-A/H2-D/B2M)1Bpe Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dma/Orl |
Alternative name | Sure/L1/GFP-FoxP3 |
Strain type | Transgenic Strains |
Allele/Transgene symbol | Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dma |
Gene/Transgene symbol | Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dma |
Information from provider
Provider | Yu Chun LONE |
Provider affiliation | INSERM |
Genetic information | GFP KI in FoxP3 gene |
Phenotypic information | Homozygous:FoxP3+ T cells co-express GFPHeterozygous:FoxP3+ T cells co-express GFP |
Breeding history | Sure/L1/GFP-FoxP3 backcross with Sure/L1 over 10 times. |
References | None available |
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | not known |
Immunocompromised | no |
Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Animals used for archiving | homozygous C57BL/6, homozygous C57BL/6 |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome / Orphanet_37042
- Immunodeficiency by defective expression of MHC class I / Orphanet_34592
- Variant ABeta2M amyloidosis / Orphanet_314652
MGI phenotypes (allele matching)
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