STOCK Pten^tm Tg(Alb1-cre) Tg(Alb1-HCVN)35Sml/Orl

Status	Available to order
EMMA ID	EM:11052
International strain name	STOCK Pten^tm Tg(Alb1-cre) Tg(Alb1-HCVN)35Sml/Orl
Alternative name	HCV +/+ AlbCRE +/+ PTEN flox/flox
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(Alb1-cre)
Gene/Transgene symbol	Tg(Alb1-cre)

Information from provider

Provider	Hervé LERAT
Provider affiliation	Equipe 18, IMRB, Inserm U955
Genetic information	These mice are conditionally invalidated for PTEN (Exon 4 and 5 floxed), they are transgenic for cre recombinase (albumin promoter) and transgenic for the full hepatitis C virus (HCV) ORF (Albumin promoter). They were generated by crossing FL-N/35 mice with PTEN flox/flox and Alb CRE+/+ mice. These mice are invalidated for PTEN in their liver and express all HCV proteins (genotype 1b) in their liver.
Phenotypic information	Homozygous: Severe non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC) Heterozygous: Severe NASH and HCC
References	None available
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	yes
Immunocompromised	no

Information from EMMA

Archiving centre	Institut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Squamous cell carcinoma of salivary glands / Orphanet_500481
Squamous cell carcinoma of the oral cavity / Orphanet_502363
Squamous cell carcinoma of the larynx / Orphanet_494550
Squamous cell carcinoma of the oropharynx / Orphanet_500478
Squamous cell carcinoma of the nasal cavity and paranasal sinuses / Orphanet_500464
Squamous cell carcinoma of the hypopharynx / Orphanet_494547
Squamous cell carcinoma of the lip / Orphanet_502366
Activated PI3K-delta syndrome / Orphanet_397596
Lhermitte-Duclos disease / Orphanet_65285
Cowden syndrome / Orphanet_201
Bannayan-Riley-Ruvalcaba syndrome / Orphanet_109
Macrocephaly-intellectual disability-autism syndrome / Orphanet_210548
Proteus-like syndrome / Orphanet_2969
Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome / Orphanet_137608
Proteus syndrome / Orphanet_744
Bilateral frontoparietal polymicrogyria / Orphanet_101070

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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STOCK Ptentm Tg(Alb1-cre) Tg(Alb1-HCVN)35Sml/Orl