- altered response to myocardial infarction / MGI
- abnormal leukocyte adhesion / MGI
- abnormal cellular extravasation / MGI
- decreased mast cell number / MGI
- decreased susceptibility to type III hypersensitivity reaction / MGI
- abnormal Kupffer cell morphology / MGI
- impaired hematopoiesis / MGI
- abnormal neutrophil physiology / MGI
- granulomatous inflammation / MGI
- increased susceptibility to parasitic infection / MGI
- immune system phenotype / MGI
- increased susceptibility to fungal infection / MGI
- increased length of allograft survival / MGI
B6.Cg-Ccr1tm1Gao Ccr5tm1Blck/Biat
Status | Available to order |
EMMA ID | EM:11147 |
International strain name | B6.Cg-Ccr1tm1Gao Ccr5tm1Blck/Biat |
Alternative name | 15-B |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Ccr5tm1Blck, |
Gene/Transgene symbol | Ccr5 |
Information from provider
Provider | Bruno Luckow |
Provider affiliation | Nephrologisches Zentrum, Arbeitsgruppe Klinische Biochemie, Klinikum der Universitaet Muenchen, Medizinische Klinik und Poliklinik IV |
Genetic information | The chemokine receptors Ccr1 and Ccr5 have been inactivated by homologous recombination in ES cells and the resulting single knock-out mice have been crossed to generate the Ccr1/Ccr5 double knock-out mice. The Ccr1/Ccr5 double-deficient mice have been backcrossed to the C57BL/6NCrl genetic background. They contain a lacZ reporter gene at the inactivated Ccr5 locus. |
Phenotypic information | Homozygous:Homozygous animals appear healthy and fertile and if unchallenged show no obvious phenotype. So far only tested in a kidney transplantation experiment. Surprisingly, weaker phenotypic effects than both single knock-outs as if the 2 deficiencies would partially neutralize each other.Heterozygous:Unknown, but most likely wildtype phenotype. |
Breeding history | N14+F3 |
References |
|
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | not known |
Information from EMMA
Archiving centre | University of Veterinary Medicine, Vienna, Austria |
Animals used for archiving | homozygous Other (please specify below) |
Disease and phenotype information
MGI phenotypes (allele matching)
Literature references
- Impaired host defense, hematopoiesis, granulomatous inflammation and type 1-type 2 cytokine balance in mice lacking CC chemokine receptor 1.;Gao J L, Wynn T A, Chang Y, Lee E J, Broxmeyer H E, Cooper S, Tiffany H L, Westphal H, Kwon-Chung J, Murphy P M, ;1997;The Journal of experimental medicine;185;1959-68; 9166425
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