B6.Cg-Ccr1tm1Gao Ccr5tm1Blck/Biat

Status

Available to order

EMMA IDEM:11147
International strain nameB6.Cg-Ccr1tm1Gao Ccr5tm1Blck/Biat
Alternative name15-B
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolCcr5tm1Blck,
Gene/Transgene symbolCcr5

Information from provider

ProviderBruno Luckow
Provider affiliationNephrologisches Zentrum, Arbeitsgruppe Klinische Biochemie, Klinikum der Universitaet Muenchen, Medizinische Klinik und Poliklinik IV
Genetic informationThe chemokine receptors Ccr1 and Ccr5 have been inactivated by homologous recombination in ES cells and the resulting single knock-out mice have been crossed to generate the Ccr1/Ccr5 double knock-out mice. The Ccr1/Ccr5 double-deficient mice have been backcrossed to the C57BL/6NCrl genetic background. They contain a lacZ reporter gene at the inactivated Ccr5 locus.
Phenotypic informationHomozygous:
Homozygous animals appear healthy and fertile and if unchallenged show no obvious phenotype. So far only tested in a kidney transplantation experiment. Surprisingly, weaker phenotypic effects than both single knock-outs as if the 2 deficiencies would partially neutralize each other.

Heterozygous:
Unknown, but most likely wildtype phenotype.
Breeding historyN14+F3
References
  • Impaired host defense, hematopoiesis, granulomatous inflammation and type 1-type 2 cytokine balance in mice lacking CC chemokine receptor 1.;Gao J L, Wynn T A, Chang Y, Lee E J, Broxmeyer H E, Cooper S, Tiffany H L, Westphal H, Kwon-Chung J, Murphy P M, ;1997;The Journal of experimental medicine;185;1959-68; 9166425
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreUniversity of Veterinary Medicine, Vienna, Austria
Animals used for archivinghomozygous Other (please specify below)

Disease and phenotype information

MGI phenotypes (allele matching)
  • altered response to myocardial infarction / MGI
  • abnormal leukocyte adhesion / MGI
  • abnormal cellular extravasation / MGI
  • decreased mast cell number / MGI
  • decreased susceptibility to type III hypersensitivity reaction / MGI
  • abnormal Kupffer cell morphology / MGI
  • impaired hematopoiesis / MGI
  • abnormal neutrophil physiology / MGI
  • granulomatous inflammation / MGI
  • increased susceptibility to parasitic infection / MGI
  • immune system phenotype / MGI
  • increased susceptibility to fungal infection / MGI
  • increased length of allograft survival / MGI

Literature references

  • Impaired host defense, hematopoiesis, granulomatous inflammation and type 1-type 2 cytokine balance in mice lacking CC chemokine receptor 1.;Gao J L, Wynn T A, Chang Y, Lee E J, Broxmeyer H E, Cooper S, Tiffany H L, Westphal H, Kwon-Chung J, Murphy P M, ;1997;The Journal of experimental medicine;185;1959-68; 9166425

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

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Practical information

Example health report
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Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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