B6.Cg-Engtm2.1Hma Gt(ROSA)26Sortm1(cre/ERT)Nat Tg(CAG-EGFP*)#Hma/H
| Status | Available to order |
| EMMA ID | EM:11360 |
| International strain name | B6.Cg-Engtm2.1Hma Gt(ROSA)26Sortm1(cre/ERT)Nat Tg(CAG-EGFP*)#Hma/H |
| Alternative name | CAG-eGFP;Engfl/fl;Rosa26-CreERT2 |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Gt(ROSA)26Sortm1(cre/ERT)Nat, |
| Gene/Transgene symbol | Gt(ROSA)26Sor |
Information from provider
| Provider | Helen Arthur |
| Provider affiliation | Institute of Genetic Medicine, Newcastle University |
| Genetic information | These mice are homozygous for three alleles: floxed endoglin allele (targeted), CAG-eGFP allele (transgenic), and Gt(ROSA)26Sor-creERT2 allele (targeted). They are described in the following paper: Redgrave RE, Tual-Chalot S, Davison BJ, Singh E, Hall D, Amirrasouli MM, Gilchrist D, Medvinsky A, Arthur HM. Cardiosphere-Derived Cells Require Endoglin for Paracrine-Mediated Angiogenesis. Stem Cell Reports. 2017 May 9;8(5):1287-1298. |
| Phenotypic information | Homozygous:The mice show no clinical abnormalities, they are viable and fertileHeterozygous:The mice show no clinical abnormalities, they are viable and fertile |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Hereditary hemorrhagic telangiectasia / Orphanet_774
Literature references
- Cardiosphere-Derived Cells Require Endoglin for Paracrine-Mediated Angiogenesis.;Redgrave Rachael E, Tual-Chalot Simon, Davison Benjamin J, Singh Esha, Hall Darroch, Amirrasouli Muhammad M, Gilchrist Derek, Medvinsky Alexander, Arthur Helen M, ;2017;Stem cell reports;8;1287-1298; 28494939
- Generation of a floxed allele of the mouse Endoglin gene.;Allinson Kathleen R, Carvalho Rita L C, van den Brink Stieneke, Mummery Christine L, Arthur Helen M, ;2007;Genesis (New York, N.Y. : 2000);45;391-5; 17506087